Document Detail


Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse.
MedLine Citation:
PMID:  8521477     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The prostaglandin endoperoxide H synthase isoform 2, cyclooxygenase 2 (COX-2), is induced at high levels in migratory and other responding cells by pro-inflammatory stimuli. COX-2 is generally considered to be a mediator of inflammation. Its isoform, COX-1, is constitutively expressed in most tissues and is thought to mediate "housekeeping" functions. These two enzymes are therapeutic targets of the widely used nonsteroidal anti-inflammatory drugs (NSAIDs). To investigate further the different physiologic roles of these isoforms, we have used homologous recombination to disrupt the mouse gene encoding COX-2 (Ptgs2). Mice lacking COX-2 have normal inflammatory responses to treatments with tetradecanoyl phorbol acetate or with arachidonic acid. However, they develop severe nephropathy and are susceptible to peritonitis.
Authors:
S G Morham; R Langenbach; C D Loftin; H F Tiano; N Vouloumanos; J C Jennette; J F Mahler; K D Kluckman; A Ledford; C A Lee; O Smithies
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cell     Volume:  83     ISSN:  0092-8674     ISO Abbreviation:  Cell     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1996-01-24     Completed Date:  1996-01-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  473-82     Citation Subset:  IM    
Affiliation:
Department of Pathology, University of North Carolina at Chapel Hill 27599-7525, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arachidonic Acid / pharmacology
Bacteriophage lambda / genetics
Base Sequence
Dinoprostone / biosynthesis
Female
Genetic Vectors / genetics*
Genotype
Homozygote
Kidney / enzymology,  pathology*
Lipopolysaccharides / pharmacology
Macrophages, Peritoneal / metabolism
Male
Mice
Mice, Mutant Strains
Molecular Sequence Data
Mortality
Otitis Externa / chemically induced
Peritoneum / pathology
Prostaglandin-Endoperoxide Synthases / genetics*,  metabolism
Tetradecanoylphorbol Acetate / pharmacology
Grant Support
ID/Acronym/Agency:
GM20069/GM/NIGMS NIH HHS; HL49227/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Lipopolysaccharides; 16561-29-8/Tetradecanoylphorbol Acetate; 363-24-6/Dinoprostone; 506-32-1/Arachidonic Acid; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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