Document Detail


Prostaglandin release in canine acute haemorrhagic pancreatitis.
MedLine Citation:
PMID:  1269976     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acute haemorrhagic pancreatitis was induced in greyhound dogs by a bile salt/trypsin injection into the main pancreatic duct. Prostaglandin-like activity in the pancreatic venous blood, right atrial blood, and arterial blood was measured by bioassay. Activity rose significantly in the pancreatic venous blood of test dogs but not in controls. Chromatographic analysis of the peritoneal exudate from the dogs with pancreatitis showed high levels of prostaglandin E-like material (mean 43 ng/ml prostaglandin E2 equivalents). It seems likely that prostaglandins contribute to the induced pancreatitis.
Authors:
G Glazer; A Bennett
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gut     Volume:  17     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1976 Jan 
Date Detail:
Created Date:  1976-08-02     Completed Date:  1976-08-02     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  22-6     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Amylases / blood
Animals
Bile Acids and Salts
Blood Pressure / drug effects
Dogs
Heart Rate / drug effects
Hemorrhage / chemically induced,  metabolism*
Pancreatitis / blood,  chemically induced,  metabolism*
Prostaglandins / metabolism*
Trypsin
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 0/Prostaglandins; EC 3.2.1.-/Amylases; EC 3.4.21.4/Trypsin
Comments/Corrections

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