Document Detail


Prostaglandin production during spontaneous labor and after treatment with RU486 in pregnant rhesus macaques.
MedLine Citation:
PMID:  7819458     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The production of prostaglandins from amnion, chorion, decidua, and myometrium was studied in a superfusion system to determine the level of prostaglandin production during late pregnancy, during spontaneous labor, and after in vivo treatment with RU486. Tissues were divided into three groups: those from pregnant control animals, those from animals receiving RU486 (20 mg/kg/day for 3 days) in vivo, and those from animals in spontaneous term labor. Tissues were collected at cesarean section and placed in the superfusion system. After a 30-min equilibration period, fractions of media were collected after passing through the tissue chambers and were assayed for prostaglandin F2 alpha (PGF2 alpha) and prostaglandin E2 (PGE2). The results showed a significant increase in PGF2 alpha from decidua of animals treated with RU486 compared to pregnant controls (pregnant: 3.01 +/- 0.45 ng/g/min; RU486: 4.45 +/- 0.28 ng/g/min; p < 0.05). There was a dramatic increase in PGE2 production by amnion from animals in spontaneous labor but not after RU486 treatment (pregnant: 0.21 +/- 0.06 ng/g/min; RU486: 0.56 +/- 0.09 ng/g/min; spontaneous labor: 5.83 +/- 0.43 ng/g/min; p < 0.01). We conclude that while progesterone is important for maintaining uterine quiescence during pregnancy, progesterone receptor blockade by RU486 does not lead to an increase in PGE2 production by amnion as is shown during normal spontaneous labor.
Authors:
G J Haluska; C A Kaler; M J Cook; M J Novy
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biology of reproduction     Volume:  51     ISSN:  0006-3363     ISO Abbreviation:  Biol. Reprod.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-02-13     Completed Date:  1995-02-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0207224     Medline TA:  Biol Reprod     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  760-5     Citation Subset:  IM    
Affiliation:
Oregon Regional Primate Research Center, Beaverton 97006.
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MeSH Terms
Descriptor/Qualifier:
Amnion / drug effects,  metabolism
Animals
Chorion / drug effects,  metabolism
Decidua / drug effects,  metabolism
Dinoprost / biosynthesis
Dinoprostone / biosynthesis
Female
Kinetics
Labor, Obstetric / physiology*
Macaca mulatta
Mifepristone / pharmacology*
Myometrium / drug effects,  metabolism
Pregnancy
Prostaglandins / biosynthesis*
Grant Support
ID/Acronym/Agency:
HD-06159/HD/NICHD NIH HHS; HD-18185/HD/NICHD NIH HHS; RR-00163/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Prostaglandins; 363-24-6/Dinoprostone; 551-11-1/Dinoprost; 84371-65-3/Mifepristone

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