Document Detail

Prostaglandin production by methylcholanthrene-transformed mouse BALB/3T3. Requirement for protein synthesis.
MedLine Citation:
PMID:  557039     Owner:  NLM     Status:  MEDLINE    
Stimulation of prostaglandin synthesis in transformed mouse fibroblasts by serum, thrombin, and bradykinin was blocked by actinomycin D and cycloheximide. These RNA and protein synthesis inhibitors did not affect prostaglandin synthetase in vitro or in vivo; nor did they affect the acylation of arachidonic acid into phospholipids. Serum-stimulated release of arachidonic acid and prostaglandins from [3H]arachidonic acid-labeled cells also was inhibited by actinomycin D and cycloheximide. RNA and protein synthesis appear to be required for expression of phospholipase activity; a prerequisite for prostaglandin synthesis by these cells.
S S Pong; S L Hong; L Levine
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  252     ISSN:  0021-9258     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  1977 Feb 
Date Detail:
Created Date:  1977-04-15     Completed Date:  1977-04-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1408-13     Citation Subset:  IM    
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MeSH Terms
Anti-Bacterial Agents / pharmacology
Arachidonic Acids / metabolism
Cell Line
Cell Transformation, Neoplastic
Cycloheximide / pharmacology
Dactinomycin / pharmacology
Emetine / pharmacology
Methylcholanthrene / pharmacology*
Prostaglandins / biosynthesis*
Prostaglandins E / biosynthesis
Prostaglandins F / biosynthesis
Protein Biosynthesis / drug effects*
Tosyl Compounds / pharmacology
Transcription, Genetic / drug effects
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Arachidonic Acids; 0/Prostaglandins; 0/Prostaglandins E; 0/Prostaglandins F; 0/Tosyl Compounds; 483-18-1/Emetine; 50-76-0/Dactinomycin; 56-49-5/Methylcholanthrene; 66-81-9/Cycloheximide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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