Document Detail

Prostaglandin production by intra-uterine tissues from periparturient sheep: use of a superfusion technique.
MedLine Citation:
PMID:  624876     Owner:  NLM     Status:  MEDLINE    
A technique for the continuous superfusion of small tissue samples in vitro has been applied to the study of prostaglandin production by ovine intra-uterine tissues. Basal and oxytocin-stimulated production of prostaglandins was studied at 120-125 days of pregnancy and after dexamethasone-induced delivery. In general, the relative rate of prostaglandin production by tissues was: foetal cotyledon = maternal cotyledon greater than myometrium and in quantitative order the prostaglandins produced were prostaglandin E (PGE) greater than prostaglandin F (PGF) = 13,14-dihydro-15-oxo-prostaglandin F (PGFM). Considerable variations was found between the rates of prostaglandin production in individual sheep. Oxytocin had no effect on the production of prostaglandins by tissues obtained before labour but myometrium and maternal cotyledon obtained at delivery exhibited a significant increase in production of PGE and PGF (though not PGFM) in response to oxytocin. Administration of arachidonic acid increased the production of PGE and PGF by the foetal cotyledon.
M D Mitchell; A P Flint
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  The Journal of endocrinology     Volume:  76     ISSN:  0022-0795     ISO Abbreviation:  J. Endocrinol.     Publication Date:  1978 Jan 
Date Detail:
Created Date:  1978-04-17     Completed Date:  1978-04-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  111-21     Citation Subset:  IM    
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MeSH Terms
Arachidonic Acids / pharmacology
Fetus / drug effects,  metabolism*
Labor, Obstetric
Oxytocin / pharmacology
Prostaglandins E / biosynthesis*
Prostaglandins F / biosynthesis*
Sheep / metabolism*
Uterus / drug effects,  metabolism*
Reg. No./Substance:
0/Arachidonic Acids; 0/Prostaglandins E; 0/Prostaglandins F; 50-56-6/Oxytocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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