Document Detail


Prostaglandin production by intra-uterine tissues from periparturient sheep: use of a superfusion technique.
MedLine Citation:
PMID:  624876     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A technique for the continuous superfusion of small tissue samples in vitro has been applied to the study of prostaglandin production by ovine intra-uterine tissues. Basal and oxytocin-stimulated production of prostaglandins was studied at 120-125 days of pregnancy and after dexamethasone-induced delivery. In general, the relative rate of prostaglandin production by tissues was: foetal cotyledon = maternal cotyledon greater than myometrium and in quantitative order the prostaglandins produced were prostaglandin E (PGE) greater than prostaglandin F (PGF) = 13,14-dihydro-15-oxo-prostaglandin F (PGFM). Considerable variations was found between the rates of prostaglandin production in individual sheep. Oxytocin had no effect on the production of prostaglandins by tissues obtained before labour but myometrium and maternal cotyledon obtained at delivery exhibited a significant increase in production of PGE and PGF (though not PGFM) in response to oxytocin. Administration of arachidonic acid increased the production of PGE and PGF by the foetal cotyledon.
Authors:
M D Mitchell; A P Flint
Related Documents :
10908536 - Near-infrared spectroscopy for fetal assessment during labour.
29656 - Continuous measurement of tissue ph in the human fetal scalp.
8979016 - Pre-term pre-labour amniorrhexis.
8743156 - Parathyroid hormone-related protein (pthrp) concentrations in human amniotic fluid duri...
24770176 - Influence of proteinuria and blood pressure on apgar scores and fetal birth weight in p...
17535086 - Microscopic chorionic pseudocysts in placental membranes: a histologic lesion of in ute...
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  The Journal of endocrinology     Volume:  76     ISSN:  0022-0795     ISO Abbreviation:  J. Endocrinol.     Publication Date:  1978 Jan 
Date Detail:
Created Date:  1978-04-17     Completed Date:  1978-04-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  111-21     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Arachidonic Acids / pharmacology
Female
Fetus / drug effects,  metabolism*
Labor, Obstetric
Oxytocin / pharmacology
Pregnancy
Prostaglandins E / biosynthesis*
Prostaglandins F / biosynthesis*
Sheep / metabolism*
Uterus / drug effects,  metabolism*
Chemical
Reg. No./Substance:
0/Arachidonic Acids; 0/Prostaglandins E; 0/Prostaglandins F; 50-56-6/Oxytocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Stability of four antifungal antimicrobics in vitro.
Next Document:  Progesterone-induced oestrogen receptors in the rat uterus.