| Prostaglandin production by intra-uterine tissues from periparturient sheep: use of a superfusion technique. | |
| | |
MedLine Citation:
|
PMID: 624876 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A technique for the continuous superfusion of small tissue samples in vitro has been applied to the study of prostaglandin production by ovine intra-uterine tissues. Basal and oxytocin-stimulated production of prostaglandins was studied at 120-125 days of pregnancy and after dexamethasone-induced delivery. In general, the relative rate of prostaglandin production by tissues was: foetal cotyledon = maternal cotyledon greater than myometrium and in quantitative order the prostaglandins produced were prostaglandin E (PGE) greater than prostaglandin F (PGF) = 13,14-dihydro-15-oxo-prostaglandin F (PGFM). Considerable variations was found between the rates of prostaglandin production in individual sheep. Oxytocin had no effect on the production of prostaglandins by tissues obtained before labour but myometrium and maternal cotyledon obtained at delivery exhibited a significant increase in production of PGE and PGF (though not PGFM) in response to oxytocin. Administration of arachidonic acid increased the production of PGE and PGF by the foetal cotyledon. |
| | |
Authors:
|
M D Mitchell; A P Flint |
Related Documents
:
|
7877066 - Clinical value of antenatal fetal pulse oximetry. 3196 - The effect of parturition on amniotic fluid lecithin concentration. 15321376 - Anaesthetic characteristics and long-term backache after obstetric epidural anaesthesia. 19647506 - Women's experiences of being induced for post-date pregnancy. 19694706 - Atypical antipsychotic (clozapine) self-poisoning in late pregnancy presenting with abs... 8008176 - Creutzfeldt-jakob disease in a pregnant woman with an implanted dura mater graft. |
Publication Detail:
|
Type: In Vitro; Journal Article |
Journal Detail:
|
Title: The Journal of endocrinology Volume: 76 ISSN: 0022-0795 ISO Abbreviation: J. Endocrinol. Publication Date: 1978 Jan |
Date Detail:
|
Created Date: 1978-04-17 Completed Date: 1978-04-17 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0375363 Medline TA: J Endocrinol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 111-21 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Arachidonic Acids / pharmacology Female Fetus / drug effects, metabolism* Labor, Obstetric Oxytocin / pharmacology Pregnancy Prostaglandins E / biosynthesis* Prostaglandins F / biosynthesis* Sheep / metabolism* Uterus / drug effects, metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Arachidonic Acids; 0/Prostaglandins E; 0/Prostaglandins F; 50-56-6/Oxytocin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Stability of four antifungal antimicrobics in vitro.
Next Document: Progesterone-induced oestrogen receptors in the rat uterus.