Document Detail

Prostaglandin modulation of the vascular effects of vasopressin in the conscious rat.
MedLine Citation:
PMID:  3931088     Owner:  NLM     Status:  MEDLINE    
Experiments were performed on conscious, male Sprague-Dawley rats to determine whether cyclooxygenase inhibition affects the pressor response to exogenous vasopressin. The rise in arterial blood pressure was tested in response to 1.0, 2.5, 5.0, and 12.5 mU synthetic arginine vasopressin both before and following cyclooxygenase inhibition with either meclofenamate or the structurally dissimilar inhibitor ibuprofen. In addition, time control experiments were also performed where only the saline vehicle for the drugs was administered. In all animals tested, the increase in arterial pressure in response to the highest three concentrations of vasopressin was greater following cyclooxygenase inhibition than before, while the saline vehicle had no effect. The baroreceptor-mediated bradycardia accompanying the rise in blood pressure was variable, but unaffected by meclofenamate or ibuprofen. It is concluded that vasodilator prostaglandins are released in response to pressor levels of vasopressin, which act to modulate the pressor response of the peptide.
B R Walker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)     Volume:  180     ISSN:  0037-9727     ISO Abbreviation:  Proc. Soc. Exp. Biol. Med.     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1985-11-20     Completed Date:  1985-11-20     Revised Date:  2007-11-02    
Medline Journal Info:
Nlm Unique ID:  7505892     Medline TA:  Proc Soc Exp Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  258-63     Citation Subset:  IM    
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MeSH Terms
Anthranilic Acids / pharmacology*
Arginine Vasopressin / pharmacology*
Blood Pressure / drug effects*
Cyclooxygenase Inhibitors
Drug Interactions
Ibuprofen / pharmacology*
Meclofenamic Acid / pharmacology*
Muscle, Smooth, Vascular / secretion
Prostaglandin Antagonists / pharmacology*
Prostaglandins / physiology*
Rats, Inbred Strains
Vasomotor System / drug effects
Reg. No./Substance:
0/Anthranilic Acids; 0/Cyclooxygenase Inhibitors; 0/Prostaglandin Antagonists; 0/Prostaglandins; 113-79-1/Arginine Vasopressin; 15687-27-1/Ibuprofen; 644-62-2/Meclofenamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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