Document Detail

Prostaglandin metabolism during growth and differentiation of the regenerating vertebrate appendage.
MedLine Citation:
PMID:  7784470     Owner:  NLM     Status:  MEDLINE    
House lizards are able to regenerate their tails. This is an ideal model to study the growth and differentiation of an organ. Prostaglandins (PGs) are local hormones having diverse and potent biological activities. In an effort to understand PG metabolism during the growth and differentiation of the regenerating lizard tail, we analysed the fatty acid (FA) composition of phospholipids are free FAs by GC, the activity of two rate-limiting enzymes (phospholipases A and C), the activity of the enzyme responsible for the oxygenation of polyunsaturated fatty acids to PGs (cyclooxygenase) and characterized the endogenous PGs by HPLC. It was observed that on the 20th day, i.e. the tissue differentiation period, there was an increase in phospholipase A activity, together with a sudden fall in the free arachidonic acid (AA) level, an increase in cyclooxygenase activity and the appearance of endogenous PGE2. PGE2 can stimulate cyclic adenosine monophosphate (cAMP) production and it may stimulate a cascade of events associated with tissue differentiation.
A Jayadeep; P Reddanna; S Sailesh; U N Das; G Ramesh; K V Kumar; V P Menon
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  52     ISSN:  0952-3278     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-07-14     Completed Date:  1995-07-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  235-9     Citation Subset:  IM    
Department of Biochemistry, University of Kerala, Trivandrum, India.
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MeSH Terms
Arachidonic Acid / metabolism
Chromatography, High Pressure Liquid
Fatty Acids / metabolism
Lizards / physiology*
Phospholipases A / metabolism
Phospholipids / metabolism
Prostaglandin-Endoperoxide Synthases / metabolism
Prostaglandins / metabolism*
Tail / physiology*
Time Factors
Type C Phospholipases / metabolism
Reg. No./Substance:
0/Fatty Acids; 0/Phospholipids; 0/Prostaglandins; 506-32-1/Arachidonic Acid; EC Synthases; EC 3.1.1.-/Phospholipases A; EC 3.1.4.-/Type C Phospholipases

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