| Prostaglandin metabolism during growth and differentiation of the regenerating vertebrate appendage. | |
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MedLine Citation:
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PMID: 7784470 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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House lizards are able to regenerate their tails. This is an ideal model to study the growth and differentiation of an organ. Prostaglandins (PGs) are local hormones having diverse and potent biological activities. In an effort to understand PG metabolism during the growth and differentiation of the regenerating lizard tail, we analysed the fatty acid (FA) composition of phospholipids are free FAs by GC, the activity of two rate-limiting enzymes (phospholipases A and C), the activity of the enzyme responsible for the oxygenation of polyunsaturated fatty acids to PGs (cyclooxygenase) and characterized the endogenous PGs by HPLC. It was observed that on the 20th day, i.e. the tissue differentiation period, there was an increase in phospholipase A activity, together with a sudden fall in the free arachidonic acid (AA) level, an increase in cyclooxygenase activity and the appearance of endogenous PGE2. PGE2 can stimulate cyclic adenosine monophosphate (cAMP) production and it may stimulate a cascade of events associated with tissue differentiation. |
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Authors:
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A Jayadeep; P Reddanna; S Sailesh; U N Das; G Ramesh; K V Kumar; V P Menon |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: 52 ISSN: 0952-3278 ISO Abbreviation: Prostaglandins Leukot. Essent. Fatty Acids Publication Date: 1995 Apr |
Date Detail:
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Created Date: 1995-07-14 Completed Date: 1995-07-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: SCOTLAND |
Other Details:
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Languages: eng Pagination: 235-9 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, University of Kerala, Trivandrum, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arachidonic Acid / metabolism Chromatography, High Pressure Liquid Fatty Acids / metabolism Lizards / physiology* Phospholipases A / metabolism Phospholipids / metabolism Prostaglandin-Endoperoxide Synthases / metabolism Prostaglandins / metabolism* Regeneration* Tail / physiology* Time Factors Type C Phospholipases / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Phospholipids; 0/Prostaglandins; 506-32-1/Arachidonic Acid; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases; EC 3.1.1.-/Phospholipases A; EC 3.1.4.-/Type C Phospholipases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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