Document Detail

Prostaglandin and fatty acid metabolism in patients with extrahepatic biliary atresia.
MedLine Citation:
PMID:  2324889     Owner:  NLM     Status:  MEDLINE    
The relationship between essential fatty acid (EFA) deficiency and disturbance of prostaglandin (PG) biosynthesis was studied in children after radical operation for extrahepatic biliary atresia (EBA). In addition, to investigate the method for treatment of postoperative EFA deficiency and disturbance of PG biosynthesis, the serum fatty acid and plasma PG levels were determined before and after supplementation of an EFA-rich powder (38 g of linoleic acid per 100 g of powder) through Suruga II enterostomy. Before administration of the EFA-rich powder, linoleic acid, arachidonic acid, PGE1, and PGF2 alpha levels were significantly lower in both good bile excretion and poor bile excretion groups than in the control group. After administration, linoleic acid and PGE1 levels significantly increased in the good bile excretion group as compared with the preadministration values. These results suggest that the supplementation of EFA-rich powder is an effective treatment for linoleic acid deficiency and disturbance of PGE1 biosynthesis in postoperative EBA patients.
T Shimizu; Y Yamashiro; K Yabuta; T Miyano; H Hayasawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  10     ISSN:  0277-2116     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-05-24     Completed Date:  1990-05-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  298-302     Citation Subset:  IM    
Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan.
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MeSH Terms
Alprostadil / biosynthesis
Bile Acids and Salts / metabolism
Biliary Atresia / metabolism*,  surgery
Cholestasis, Extrahepatic / metabolism*,  surgery
Fatty Acids, Essential / administration & dosage,  deficiency*
Follow-Up Studies
Linoleic Acid
Linoleic Acids / administration & dosage,  metabolism
Prostaglandins / biosynthesis*
Reg. No./Substance:
0/Bile Acids and Salts; 0/Fatty Acids, Essential; 0/Linoleic Acids; 0/Prostaglandins; 2197-37-7/Linoleic Acid; 745-65-3/Alprostadil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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