Document Detail

Prostaglandin J2 and its metabolites promote neurite outgrowth induced by nerve growth factor in PC12 cells.
MedLine Citation:
PMID:  10222233     Owner:  NLM     Status:  MEDLINE    
Although A- and J-type prostaglandins (PG's) arrest the cell cycle at the G1 phase in vitro and suppress tumor growth in vivo, their effects on neuronal cells have not so far been clarified. Here, we found promotion of neurite outgrowth as a novel biological function of PGJ's. In PC12h cells, PGJ's (PGJ2, Delta12-PGJ2 and 15-deoxy-Delta12,14-PGJ2) promoted neurite outgrowth in the presence of nerve growth factor (NGF), whereas they themselves did not show such a promotion. The potency of promoting neurite outgrowth was PGJ2 < Delta12-PGJ2 < 15-deoxy-Delta12,14-PGJ2. However, troglitazone, an activator of peroxisome proliferator-activated receptorgamma (PPARgamma), and other PG's including PGA1, PGA2 and PGD2 did not promote neurite outgrowth. These results suggest that PGJ's promote neurite outgrowth independently of PPARgamma activation.
T Satoh; K Furuta; M Suzuki; Y Watanabe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  258     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-05-27     Completed Date:  1999-05-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  50-3     Citation Subset:  IM    
Copyright Information:
Copyright 1999 Academic Press.
Department of Neuroscience, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita-shi, Osaka, 565-0874, Japan.
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MeSH Terms
Nerve Growth Factors / pharmacology*
Neurites / drug effects*
PC12 Cells
Prostaglandin D2 / analogs & derivatives*,  metabolism,  physiology
Reg. No./Substance:
0/Nerve Growth Factors; 41598-07-6/Prostaglandin D2; 60203-57-8/9-deoxy-delta-9-prostaglandin D2

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