Document Detail

Prostaglandin H synthase and vascular function.
MedLine Citation:
PMID:  11597987     Owner:  NLM     Status:  MEDLINE    
Prostaglandin H synthase (PGHS) is a rate-limiting enzyme in the production of prostaglandins and thromboxane, which are important regulators of vascular function. Under normal physiological conditions, PGHS-dependent vasodilators (such as prostacyclin) modulate vascular tone. However, PGHS-dependent vasoconstriction (mediated by thromboxane and/or its immediate precursor, PGH(2)) predominates in some vascular pathologies (eg, systemic hypertension, diabetes, cerebral ischemia, and aging). This review will discuss the role of PGHS-dependent modulation of vascular function in a number of vascular beds (systemic, pulmonary, cerebral, and uterine) with an emphasis on vascular pathophysiology. Moreover, the specific contributions of the different isoforms (PGHS-1 and PGHS-2) are discussed. Understanding the role of PGHS in vascular function is of particular importance because they are the targets of the commonly used nonsteroidal antiinflammatory drugs (NSAIDs), which include aspirin and ibuprofen. Importantly, with the advent of specific PGHS-2 inhibitors for treatment of conditions such as chronic inflammatory disease, it is an opportune time to review the data regarding PGHS-dependent modulation of vascular function.
S T Davidge
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Circulation research     Volume:  89     ISSN:  1524-4571     ISO Abbreviation:  Circ. Res.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-12     Completed Date:  2001-10-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  650-60     Citation Subset:  IM    
Perinatal Research Centre, Departments of Ob/Gyn and Physiology, University of Alberta, Edmonton, Alberta, Canada.
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MeSH Terms
Blood Vessels / drug effects,  enzymology*
Cyclooxygenase Inhibitors / pharmacology
Endothelium, Vascular / enzymology
Microcirculation / drug effects,  physiology
Prostaglandin-Endoperoxide Synthases / metabolism*
Prostaglandins / metabolism
Vasoconstriction / physiology
Vasodilation / physiology
Vasomotor System / drug effects,  enzymology*
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 0/Prostaglandins; EC Synthases

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