Document Detail


Prostaglandin F2 alpha-isopropylester eye drops: effect on intraocular pressure in open-angle glaucoma.
MedLine Citation:
PMID:  2611194     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In 30 patients with previously untreated open-angle glaucoma an intraocular pressure (IOP) curve was taken before and during treatment with PGF2 alpha-isopropylester (PGF2 alpha-IE) eye drops in one eye. Compared with the pretreatment IOP, the PGF2 alpha-IE induced a slowly increasing reduction in IOP. Just before the first dose the IOP was 31.4 (SEM 1.6) mm Hg. When corrected for the fall in pressure observed in the fellow eye the largest reduction, 5.8 (SEM 0.7) mm Hg (p less than 0.001), was obtained 24 hours later, that is, 12 hours after the second dose. In a subgroup of 10 patients the treatment was continued for one week. In this group the final pretreatment IOP was 25.9 (SEM 1.3) mm Hg. The reduction 24 hours later was 4.5 (SEM 0.6) mm Hg (p less than 0.001). The effect was maintained and even slightly increased during the week, and on the seventh day of treatment the IOP reduction ranged between 4.8 and 7.6 mm Hg compared with the pretreatment IOP. No serious subjective or objective side effects were observed.
Authors:
J Villumsen; A Alm; M Söderström
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  73     ISSN:  0007-1161     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-02-28     Completed Date:  1990-02-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  975-9     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, University Hospital, Umeå, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Aged
Dinoprost / administration & dosage,  analogs & derivatives*,  therapeutic use
Female
Glaucoma, Open-Angle / drug therapy*
Humans
Intraocular Pressure / drug effects*
Male
Middle Aged
Ophthalmic Solutions
Chemical
Reg. No./Substance:
0/Ophthalmic Solutions; 53764-90-2/prostaglandin F2 isopropyl ester; 551-11-1/Dinoprost
Comments/Corrections

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