Document Detail


Prostaglandin F2 alpha for interrupting pregnancy, managing intrauterine death and molar pregnancy and inducing labor.
MedLine Citation:
PMID:  6102058     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serial intramuscular injections of 250 microgram of 15 (S), 15-methyl-prostaglandin F2 alpha were given to 105 women every 1-3 hours in an attempt to induce second-trimester abortion (N = 80) or labor (N = 25), the latter because of late intrauterine death or anencephaly. The treatment was highly successful; the cumulative expulsion rates at 12 and 24 hours were 69% and 95%, respectively. There were no serious complications, and significant alterations in the mother's vital signs were uncommon. Gastrointestinal side effects are tolerable if the woman is properly premedicated and maintained on the antiemetic, antidiarrheic and analgesic treatments.
Serial intramuscular injections of 250 mcg of 15(S,15-methyl-prostaglandin F2alpha were given to 105 women every 1-3 hours in an attempt to induce second trimester abortion (N=80) or labor (N=25). Patients were divided into 5 groups: those with missed abortions; those with pregnancy terminations; those with molar pregnancy; those with intrauterine death; and those where labor was induced with a live anencephalic fetus. The treatment was highly successful; the cumulative expulsion rates at 12 and 24 hours were 69% and 95% respectively. There were no serious complications, and significant alterations in the mother's vital signs were uncommon. Gastrointestinal side effects are tolerable if the woman is properly premedicated and maintained on the antiemetic, antidiarrheic, and analgesic treatments.
Authors:
H de Gezelle; M Thiery; W Parewijck; J M Decoster
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  17     ISSN:  0020-7292     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:    1980 Jan-Feb
Date Detail:
Created Date:  1980-05-30     Completed Date:  1980-05-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  362-7     Citation Subset:  IM; J    
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MeSH Terms
Descriptor/Qualifier:
Abortion, Induced*
Abortion, Missed / therapy
Adolescent
Adult
Female
Fetal Death / therapy
Gastrointestinal Diseases / chemically induced
Humans
Hydatidiform Mole / therapy
Injections, Intramuscular
Labor, Induced*
Pregnancy
Pregnancy Complications / therapy*
Pregnancy Trimester, Second
Prostaglandins F, Synthetic* / administration & dosage,  adverse effects
Uterine Neoplasms / therapy
Chemical
Reg. No./Substance:
0/Prostaglandins F, Synthetic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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