Document Detail


Prostaglandin F production by tissue explants from term pregnancies.
MedLine Citation:
PMID:  6106578     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Explants of various tissues obtained from pregnant women at term and from nonpregnant women were maintained in culture and their capacities to synthesize prostaglandin (PGF) were evaluated. Myometrial and decidual tissues from pregnant women produced significantly smaller amounts of PGF than those from nonpregnant women, suggesting that PGF production is inhibited during gestation. Decidual PGF synthesis was also inhibited by the addition of progesterone, estradiol or indomethacin. The PGF synthesis of the chorion of women in labor was lower than that of women not in labor. In the later group, the cohrion, decidua and myometrium produced significant amounts of PGF, but amniotic PGF production was negligible. Our findings show that the decidua and chorion, as well as the myometrium, are potentially important sources of PGF production. PGF synthesis during pregnancy also may be affected by local inhibitory influences.
Authors:
R Lackritz; W R Cohen; D Tulchinsky
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  17     ISSN:  0020-7292     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:    1980 May-Jun
Date Detail:
Created Date:  1980-12-16     Completed Date:  1980-12-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  585-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Culture Techniques
Decidua / physiology
Female
Humans
Labor, Obstetric
Pregnancy
Prostaglandins F / secretion*
Uterus / physiology*
Chemical
Reg. No./Substance:
0/Prostaglandins F

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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