Document Detail

Prostaglandin E2 is involved in adrenocorticotrophic hormone release during swimming exercise in rats.
MedLine Citation:
PMID:  1668757     Owner:  NLM     Status:  MEDLINE    
1. We found that adrenocorticotrophic hormone (ACTH) release in rats induced by acute swimming exercise or by an intravenous injection of human recombinant interleukin-1 beta (IL-1 beta) was significantly attenuated after chronic exercise. 2. Since involvement of prostaglandins in the ACTH response induced by IL-1 is well known, we investigated the effect of indomethacin, an inhibitor of prostaglandin synthesis, on the ACTH response induced in rats by acute swimming exercise. Pretreatment with an intravenous injection of indomethacin significantly suppressed the ACTH response induced by exercise. The effect of indomethacin (1 and 10 mg/kg) on the ACTH response was dose-dependent. 3. The effect of chronic exercise on the exercise-induced changes in the plasma concentration of prostaglandin E2 was investigated. The plasma concentration of prostaglandin E2 significantly increased after acute exercise in both the control and the chronically exercised rats. However, the increase in the plasma level of prostaglandin E2 was significantly smaller in the chronically exercised group than in the control group. 4. Intravenous injections of prostaglandin E2 produced dose-dependent increases in the plasma concentration of ACTH in rats. 5. The present results suggest that an increase in prostaglandin E2 levels in plasma is involved in the development of the ACTH response induced by exercise.
T Watanabe; A Morimoto; Y Sakata; N C Long; N Murakami
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of physiology     Volume:  433     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1992-12-04     Completed Date:  1992-12-04     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  719-25     Citation Subset:  IM    
Department of Physiology, Yamaguchi University School of Medicine, Japan.
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MeSH Terms
Adrenocorticotropic Hormone / blood,  secretion*
Dinoprostone / blood,  physiology*
Interleukin-1 / pharmacology
Physical Exertion / physiology*
Rats, Wistar
Reg. No./Substance:
0/Interleukin-1; 363-24-6/Dinoprostone; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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