| Prostaglandin E2-induced fever in young and old Long-Evans rats. | |
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MedLine Citation:
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PMID: 10463641 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aging is associated with a blunted or absent fever response to naturally occurring infections or to the peripheral administration of bacterial products and proinflammatory cytokines. We have recently shown that old Long-Evans rats are not defective in their capacity to develop a fever in response to brain administration of interleukin-1beta (IL-1beta). Here, we investigated the fever response of young (3-5-month) and old (24-26-month) Long-Evans rats to the intracerebroventricular (i.c.v.) microinfusion of prostaglandin E2 (PGE2), a final common mediator for the production of fever in the brain. Core body temperature was monitored by telemetry in freely moving rats. i.c.v. administered PGE2 (100 ng) induced comparable increases in body temperature in young and old Long-Evans rats. In the two groups, PGE2-induced fever was similar both in latency-to-peak fever and maximal fever response. These data, and the previous data on IL-1beta, demonstrate that the brains of old and young rats are similar with respect to fever generation in response to the i.c.v. administration of two classes of immunomodulators. |
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Authors:
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E Satinoff; E Peloso; C R Plata-Salamn |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Physiology & behavior Volume: 67 ISSN: 0031-9384 ISO Abbreviation: Physiol. Behav. Publication Date: 1999 Aug |
Date Detail:
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Created Date: 1999-10-21 Completed Date: 1999-10-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 149-52 Citation Subset: IM |
Affiliation:
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Department of Psychology, University of Deleware, Newark 19716-2590, USA. satinoff@udel.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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drug effects* Animals Body Temperature / drug effects* Brain / drug effects Dinoprostone / pharmacology* Fever / chemically induced Injections, Intraventricular Interleukin-1 / pharmacology Male Rats Rats, Long-Evans Telemetry |
| Grant Support | |
ID/Acronym/Agency:
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R01-MH41138/MH/NIMH NIH HHS; R01-MH56082/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-1; 363-24-6/Dinoprostone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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