Document Detail

Prostaglandin E2 and epinephrine participate in cyclical reduction of coronary blood pressure and flow.
MedLine Citation:
PMID:  650909     Owner:  NLM     Status:  MEDLINE    
The effects of the agents that inhibited synthesis of prostaglandins (PGs) and thromboxanes (TXs) on cyclical reduction of blood flow in partially constricted coronary artery of anesthetized dog were examined. The cyclical reduction of coronary blood flow was eliminated by intravenous injections of aspirin that inhibited synthesis of endoperoxides, of benzydamine that inhibited synthesis of endoperoxides and TX A2, and of phenylbutazone that inhibited synthesis of PG E2, but was not of reduced glutathione that inhibited synthesis of TX A2 and accelerated synthesis of PG E2. In the preparations in which cyclical reduction of blood flow did not occur spontaneously, intracoronary injection of PG E2, but not of PG F2a, induced the cyclical reduction. The cyclical reduction was also induced by intravenous injections of epinephrine and reduced glutathione that accelerated synthesis of PG E2. The results indicate participation of PG E2 in the cyclical reduction of coronary blood flow.
Y Uchida; N Yoshimoto; S Murao
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese heart journal     Volume:  19     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  1978 Mar 
Date Detail:
Created Date:  1978-07-24     Completed Date:  1978-07-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  281-96     Citation Subset:  IM    
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MeSH Terms
Aspirin / pharmacology
Blood Flow Velocity
Blood Pressure*
Coronary Circulation* / drug effects
Epinephrine / pharmacology,  physiology*
Glutathione / pharmacology
Platelet Aggregation / drug effects
Prostaglandins E / biosynthesis,  physiology*
Thromboxane A2 / biosynthesis
Reg. No./Substance:
0/Prostaglandins E; 50-78-2/Aspirin; 51-43-4/Epinephrine; 57576-52-0/Thromboxane A2; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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