| Prostaglandin E2 and the bovine sphincter pupillae. | |
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MedLine Citation:
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PMID: 4777704 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The bovine isolated sphincter pupillae incubated in Krebs solution releases a biologically active substance tentatively identified as prostaglandin E(2).2. The prostaglandin did not appear to be of neural origin or to result merely from tissue degeneration.3. The spontaneous release of prostaglandin E(2)-like material was related to the tone of the sphincter. Output increased as tone was acquired after setting up the tissue and fell when various procedures were used to reduce the tone.4. Low concentrations of E and F-type prostaglandins produced slow, well-sustained contractions of the atonic sphincter, prostaglandin E(2) being the most potent of those tested. The responses to prostaglandin E(2) were antagonized selectively by a prostaglandin antagonist SC-19220 (a dibenzoxazepine derivative) which in higher concentrations caused dose-dependent relaxations of the preparation.5. Prostaglandins did not appear to modulate transmission from nerve to muscle in the sphincter.6. The hypothesis that prostaglandin E(2) might be produced to act as a local hormone causing tonic contraction of the sphincter pupillae is discussed. |
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Authors:
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J Posner |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: British journal of pharmacology Volume: 49 ISSN: 0007-1188 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 1973 Nov |
Date Detail:
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Created Date: 1974-04-05 Completed Date: 1974-04-05 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 415-27 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology Animals Calcium Cattle Chromatography, Paper Chromatography, Thin Layer Dibenzoxazepines / pharmacology Dose-Response Relationship, Drug Electric Stimulation Iris / drug effects*, secretion Kymography Muscle Tonus / drug effects Oxygen Consumption Prostaglandins / pharmacology*, secretion |
| Chemical | |
Reg. No./Substance:
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0/Dibenzoxazepines; 0/Prostaglandins; 51-84-3/Acetylcholine; 7440-70-2/Calcium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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