| Prostaglandin E2 and the Pathogenesis of Pulmonary Fibrosis. | |
| | |
MedLine Citation:
|
PMID: 21421906 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Prostaglandin E2 (PGE2) is a bioactive eicosanoid which regulates many biologically important processes in part due to its ability to signal through 4 distinct G-protein coupled receptors with differential signaling activity and unique expression patterns in different cell types. While PGE2 has been linked to malignancy in many organs, it is believed to largely play a beneficial role in the setting of fibrotic lung disease. This is in large part due to the ability of PGE2 to limit many of the pathobiologic features of lung fibroblasts and myofibroblasts, including the ability of PGE2 to limit fibroblast proliferation, migration, collagen secretion, and as originally reported in Am. J. Respir. Cell Mol Biol. by us in 2003, the ability to limit transforming growth factor (TGF)β-induced myofibroblast differentiation. Unfortunately, in the setting of lung fibrosis, PGE2 production and signaling is often diminished. In the last 8 years, significant advances have been made to better understand the dysregulation of PGE2 production and signaling in the setting of lung fibrosis. We also have a clearer picture of how PGE2 inhibits myofibroblast differentiation and the receptor signaling pathways that can influence fibroblast proliferation. This review highlights these recent advances and offers new insights into the potential ways that PGE2 and its downstream signals can be regulated for therapeutic benefit in a disease that currently has no validated treatment options. |
| | |
Authors:
|
Paul D Bozyk; Beth B Moore |
Related Documents
:
|
11168616 - Role and significance of the complement system in mucosal immunity: particular referenc... 21415216 - Role of erk-bim and stat3-survivin signaling pathways in alk inhibitor-induced apoptosi... 18199646 - Complement is an essential component of the immune response to adeno-associated virus v... 3902986 - Activation of the alternative pathway of complement by skin immune deposits. 3011016 - The pharmacological mediation of epithelial cell proliferation. 16364816 - Visceral pain and public speaking stress: neuroendocrine and immune cell responses in h... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-18 |
Journal Detail:
|
Title: American journal of respiratory cell and molecular biology Volume: - ISSN: 1535-4989 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8917225 Medline TA: Am J Respir Cell Mol Biol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mondini Malformation Associated With Diastematomyelia and Presenting With Recurrent Meningitis.
Next Document: ICOS Controls T Cell Migration to the Lungs via Down-Regulation of CCR7 and CD62L.