| Prostaglandin E2 (PGE2) inhibits an IUD-induced premature luteolysis in sheep. | |
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MedLine Citation:
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PMID: 3867068 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fifteen ewes were assigned as they came into estrus to one of three randomized treatment groups: 1. Sham IUD + Vehicle, 2. IUD + Vehicle, and 3. IUD + PGE2 in Vehicle. An IUD was inserted adjacent to the luteal-bearing ovary of unilaterally ovariectomized ewes on day 3 postestrus. Vehicle (Na2CO3) or PGE2 (500 micrograms) in vehicle was given every 4 hours intrauterine through an indwelling uterine cannula from day 3 postestrus until ewes returned to estrus. Luteolysis was advanced in both the Sham IUD and IUD groups receiving vehicle. An IUD-induced premature luteolysis was prevented by PGE based on daily concentrations of progesterone in peripheral blood and the extended interestrous interval. It is concluded that chronic intrauterine injections of PGE2 (500 micrograms) every four hours can prevent an IUD-induced premature luteolysis. It is also concluded that an IUD-induced premature luteolysis is not necessarily through uterine distention. |
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Authors:
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C Weems; M Huie; R Magness; G Hoyer; G Whysong |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and medicine Volume: 20 ISSN: 0262-1746 ISO Abbreviation: Prostaglandins Leukot Med Publication Date: 1985 Dec |
Date Detail:
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Created Date: 1986-02-24 Completed Date: 1986-02-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8206868 Medline TA: Prostaglandins Leukot Med Country: SCOTLAND |
Other Details:
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Languages: eng Pagination: 267-73 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Corpus Luteum / drug effects, physiology* Dinoprostone Estrus / drug effects Female Intrauterine Devices* Ovariectomy Progesterone / blood Prostaglandins E / pharmacology* Sheep |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins E; 363-24-6/Dinoprostone; 57-83-0/Progesterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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