| Prostaglandin E1 treatment of leg ulcers caused by venous or arterial incompetence. | |
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MedLine Citation:
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PMID: 6162314 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An open and a double-blind study were undertaken on patients with leg ulcers caused mainly by venous (VI) or arterial incompetence (AI). They were treated with intravenous infusions or injections of prostaglandin E1 (PGE1). Eight of 10 patients in the open study experienced relief of pain and a complete or almost complete healing of their ulcers. In the double-blind study (20 patients) 4 out of 5 patients with a history of leg ulcers due to VI for more than 5 year responded to the PGE1 treatment, compared with one of 5 treated with saline. In the saline group 3 more patients with VI of shorter duration improved. In 3 of 5 patients of PGE1 with ulcers due to AI the original ulcer area was reduced by 78--65% after 70 days, while in the 2 remaining cases healing occurred later on. No effect was noted in the 2 patients with ulcers due to AI who received saline infusions. The results indicate the beneficial effect of PGE1 on pain and healing in leg ulcers caused by peripheral vascular disease. |
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Authors:
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H Beitner; H Hammar; A G Olsson; N Thyresson |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Acta dermato-venereologica Volume: 60 ISSN: 0001-5555 ISO Abbreviation: Acta Derm. Venereol. Publication Date: 1980 |
Date Detail:
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Created Date: 1981-04-24 Completed Date: 1981-04-24 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370310 Medline TA: Acta Derm Venereol Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 425-30 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Arterial Occlusive Diseases / complications Clinical Trials as Topic Double-Blind Method Female Humans Leg Ulcer / diagnosis, drug therapy*, etiology Male Middle Aged Prostaglandins E / adverse effects, therapeutic use* Varicose Ulcer / drug therapy Venous Insufficiency / complications |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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