Document Detail

Prostaglandin E1 in infants with pulmonary atresia.
MedLine Citation:
PMID:  741285     Owner:  NLM     Status:  MEDLINE    
Infants with pulmonary atresia are frequently dependent upon the patency of the ductus arteriosus for adequate pulmonary blood flow. Endogenous production of a dilator prostaglandin probably maintains patency of the ductus in utero. Infusion of prostaglandin E1 (PGE1) 0,1 microgram/kg/min was used in 6 infants with pulmonary atresia to increase pulmonary blood flow and systemic oxygenation. The infusion improved the clinical condition of the infants and diminished the degree of central cyanosis. In 3 cases serial measurement of systemic arterial oxygen tension showed a sustained increase. There were no deleterious side-effects. During cardiac catheterization and preparation for operation, PGE1 provides a valuable means of maintaining pulmonary blood flow in infants with pulmonary atresia and a ductus arteriosus.
E K Weir; R E Matisonn; E Losman; E Chesler
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde     Volume:  54     ISSN:  0256-9574     ISO Abbreviation:  S. Afr. Med. J.     Publication Date:  1978 Oct 
Date Detail:
Created Date:  1979-04-26     Completed Date:  1979-04-26     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  0404520     Medline TA:  S Afr Med J     Country:  SOUTH AFRICA    
Other Details:
Languages:  eng     Pagination:  700-2     Citation Subset:  IM    
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MeSH Terms
Ductus Arteriosus, Patent / drug therapy*
Infant, Newborn
Infant, Newborn, Diseases / drug therapy*
Lung / abnormalities*
Prostaglandins E / therapeutic use*
Pulmonary Circulation / drug effects
Reg. No./Substance:
0/Prostaglandins E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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