| Prostaglandin E1 in infants with pulmonary atresia. | |
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MedLine Citation:
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PMID: 741285 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Infants with pulmonary atresia are frequently dependent upon the patency of the ductus arteriosus for adequate pulmonary blood flow. Endogenous production of a dilator prostaglandin probably maintains patency of the ductus in utero. Infusion of prostaglandin E1 (PGE1) 0,1 microgram/kg/min was used in 6 infants with pulmonary atresia to increase pulmonary blood flow and systemic oxygenation. The infusion improved the clinical condition of the infants and diminished the degree of central cyanosis. In 3 cases serial measurement of systemic arterial oxygen tension showed a sustained increase. There were no deleterious side-effects. During cardiac catheterization and preparation for operation, PGE1 provides a valuable means of maintaining pulmonary blood flow in infants with pulmonary atresia and a ductus arteriosus. |
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Authors:
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E K Weir; R E Matisonn; E Losman; E Chesler |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde Volume: 54 ISSN: 0256-9574 ISO Abbreviation: S. Afr. Med. J. Publication Date: 1978 Oct |
Date Detail:
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Created Date: 1979-04-26 Completed Date: 1979-04-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0404520 Medline TA: S Afr Med J Country: SOUTH AFRICA |
Other Details:
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Languages: eng Pagination: 700-2 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Ductus Arteriosus, Patent
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drug therapy* Female Humans Infant Infant, Newborn Infant, Newborn, Diseases / drug therapy* Lung / abnormalities* Male Prostaglandins E / therapeutic use* Pulmonary Circulation / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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