Document Detail

Prostaglandin E analogue inhibition of intrinsic factor release.
MedLine Citation:
PMID:  3140367     Owner:  NLM     Status:  MEDLINE    
In many mammalian species (including humans) the parietal cell secretes both acid and intrinsic factor (IF). The aim of this study was to examine the direct effect of prostaglandin E analogues on basal and stimulated IF release in isolated, enriched rabbit parietal cells. The effects of graded concentrations (10(-12) to 10(-6) M) of 16,16-dimethyl prostaglandin E2 (DMPGE2) and 16-methyl,16-hydroxyl prostaglandin E1 (misoprostol) on submaximal histamine-stimulated (10(-6) M) secretion were tested. Both analogues failed to alter basal release of IF or aminopyrine accumulation (indirect measure of acid secretion). Increasing concentrations of DMPGE2 resulted in a dose-dependent inhibition of IF release (22 +/- 8% decrease at 10(-9) M; p less than 0.05) and a maximal effective response at 10(-7) M (54 +/- 9%; p less than 0.005). Dose-dependent inhibition of IF secretion was also observed with increasing concentrations of misoprostol, with a 22 +/- 7% decrease at 10(-9) M (p less than 0.05) and maximal effective inhibition at 10(-6) M (47 +/- 8%; p less than 0.01). Misoprostol and DMPGE2 inhibition of acid secretion paralleled IF release. Prostaglandin analogues appear to block IF release potently in histamine-stimulated parietal cells.
K A Zucker; T E Adrian; G H Ballantyne; I M Modlin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  23     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-11-23     Completed Date:  1988-11-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  650-4     Citation Subset:  IM    
Dept. of Surgery, Yale University School of Medicine, West Haven, Connecticut 06516.
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MeSH Terms
Alprostadil / analogs & derivatives*,  pharmacology
Gastric Acid / secretion
Histamine / pharmacology
Intrinsic Factor / secretion*
Parietal Cells, Gastric / drug effects*
Prostaglandins E, Synthetic / pharmacology*
Reg. No./Substance:
0/Prostaglandins E, Synthetic; 41692-15-3/16,16-dimethylprostaglandin E; 51-45-6/Histamine; 59122-46-2/Misoprostol; 745-65-3/Alprostadil; 9008-12-2/Intrinsic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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