| Prostaglandin D2 synthase and its post-translational modifications in neurological disorders. | |
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MedLine Citation:
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PMID: 16259013 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prostaglandin D2 synthase (PGDS) (beta-trace protein) is a highly abundant cerebrospinal fluid (CSF) glycoprotein. A number of studies have been performed to determine the potential value of this protein for the diagnosis of various neurological disorders. The measurement of total PGDS levels in CSF has proved marginally useful for this purpose, but promising results were obtained while investigating changes in the posttranslational modifications (PTM) pattern. Using 2-DE analysis, we previously showed that PGDS is differentially expressed in ante- and post mortem CSF samples. In the present study, we examined whether the PGDS isoforms may help to distinguish stroke and neurodegenerative disease patients from healthy subjects. The pattern of PGDS PTM was analyzed in CSF from patients with various neurological disorders (n = 44) using IEF/immunoblotting techniques. Strong alterations of this pattern were detected in patients with different forms of degenerative dementia. These findings are consistent with PGDS being altered in some neurological diseases and provide new opportunities for clinical applications. |
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Authors:
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Pierre Lescuyer; Alberto Gandini; Pierre R Burkhard; Denis F Hochstrasser; Jean-Charles Sanchez |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Electrophoresis Volume: 26 ISSN: 0173-0835 ISO Abbreviation: Electrophoresis Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-12-05 Completed Date: 2006-03-02 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8204476 Medline TA: Electrophoresis Country: Germany |
Other Details:
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Languages: eng Pagination: 4563-70 Citation Subset: IM |
Affiliation:
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Biomedical Proteomics Research Group, Department of Bioinformatics and Structural Biology, Geneva University, Geneva, Switzerland. Pierre.Lescuyer@medecine.unige.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Biological Markers / cerebrospinal fluid Electrophoresis, Gel, Two-Dimensional Female Humans Intramolecular Oxidoreductases / cerebrospinal fluid*, metabolism Lipocalins Male Middle Aged Neurodegenerative Diseases / cerebrospinal fluid*, diagnosis Protein Isoforms / cerebrospinal fluid Protein Processing, Post-Translational* Stroke / cerebrospinal fluid*, diagnosis |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Lipocalins; 0/Protein Isoforms; EC 5.3.-/Intramolecular Oxidoreductases; EC 5.3.99.2/prostaglandin R2 D-isomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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