Document Detail


Prostaglandin D2 (PGD2)--a potent coronary vasoconstrictor agent in the guinea pig isolated heart.
MedLine Citation:
PMID:  652054     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The action of prostaglandin D2 (PGD2) on myocardial force of contraction (MFC) and coronary vascular resistance (CVR) was studied in the isovolumetrically perfused guinea pig heart at constant driving frequency (180 beats/min). PGD2 (2 . 10(-9) - 1 . 10(-6) M) produced a concentration-dependent increase in the CVR while the MFC remained unchanged. The ED50 (50% of maximum response) of the coronary vasomotor action amounted to 4.3 . 10(-8) M PGD2. The results give evidence for a potent coronary vasoconstrictor activity of PGD2.
Authors:
K Schr?r
Related Documents :
16377924 - Comparable prognostic value of vasodilator response to acetylcholine in brachial and co...
9229294 - The effect of reduced myocardial cyclic amp content on the response to milrinone in the...
10751644 - Chronic exercise training preserves prostaglandin-induced dilation of epicardial corona...
6130144 - Concentration and time-dependent relationships between isosorbide dinitrate-induced rel...
8357774 - Effects of the single and repeated administration of benazepril on systemic and forearm...
15680834 - Coronary endarterectomy and stent removal in patients with in-stent restenosis.
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  302     ISSN:  0028-1298     ISO Abbreviation:  Naunyn Schmiedebergs Arch. Pharmacol.     Publication Date:  1978 Mar 
Date Detail:
Created Date:  1978-07-15     Completed Date:  1978-07-15     Revised Date:  2010-03-12    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  61-2     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Coronary Vessels / drug effects*
Female
Guinea Pigs
Male
Myocardial Contraction / drug effects
Prostaglandins / pharmacology*
Prostaglandins D / pharmacology*
Vasoconstrictor Agents*
Chemical
Reg. No./Substance:
0/Prostaglandins; 0/Prostaglandins D; 0/Vasoconstrictor Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Vasoconstriction after adenosine and inosine in the rat isolated hindlimb abolished by blockade of t...
Next Document:  Tissues concentration and excretion of deslanatoside C-3H in newborn and growing rabbits.