| Prostacyclin, thromboxane A and the effect of low-dose ASA in pregnancies at high risk for hypertensive disorders. | |
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MedLine Citation:
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PMID: 15548142 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim of this study was to investigate the prostanoid production in pregnancies at high risk for hypertensive disorders, and the effect of low-dose acetylsalicylic acid (ASA) on prostanoids. MATERIAL AND METHODS: Ninety women with a bilateral notching in uterine arteries screened by Doppler ultrasound at 12-14 gestational weeks were randomized to the ASA (0.5 mg/kg/day) or placebo group. Forty-three women in both groups were followed up throughout the pregnancy. Urine samples were taken at baseline, and at 24-26 and 32-34 weeks of gestation to determine the urinary 11-dehydrothromboxane B(2) (u-11-dehydro-TxB(2)) and 2,3-dinor-6-keto-prostaglandin F(1alpha) (u-2,3-dinor-6-keto-PGF(1alpha)), the metabolites of thromboxane A(2) and prostacyclin, respectively. RESULTS: In the pregnancies with pregnancy-induced hypertension (PIH) before 37 gestational weeks, the 2,3-dinor-6-keto-PGF(1alpha)/11-dehydro-TxB(2) ratio did not increase as much as in other pregnancies (P = 0.028). In the placebo group pregnancies with preeclampsia had significantly lower 2,3-dinor-6-keto-PGF(1alpha) (P = 0.019) at 12-14 weeks of gestation compared to other pregnancies. In the placebo group the 2,3-dinor-6-keto-PGF(1alpha)/11-dehydroTxB(2) ratio remained unchanged throughout the pregnancy, with no significant difference between pregnancies with a normal or an adverse outcome. In the ASA group the 2,3-dinor-6-keto-PGF(1alpha)/11-dehydro-TxB(2) ratio increased (P < 0.001, early vs. midpregnancy). Again, the changes were similar in pregnancies with a normal or an adverse outcome. CONCLUSION: The balance of prostacyclin and thromboxane A(2) shifted in an unfavorable direction in pregnancies complicated by PIH. ASA had a favorable effect on the prostanoids. |
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Authors:
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Merja Vainio; Asko Riutta; Anna-Maija Koivisto; Johanna Mäenpää |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta obstetricia et gynecologica Scandinavica Volume: 83 ISSN: 0001-6349 ISO Abbreviation: Acta Obstet Gynecol Scand Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-11-19 Completed Date: 2004-12-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370343 Medline TA: Acta Obstet Gynecol Scand Country: Denmark |
Other Details:
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Languages: eng Pagination: 1119-23 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Hyvinkää Hospital, Hyvinkää, Finland. merja.vainio@hus.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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6-Ketoprostaglandin F1 alpha
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analogs & derivatives*,
urine Aspirin / administration & dosage* Cyclooxygenase Inhibitors / administration & dosage* Epoprostenol / analogs & derivatives, metabolism*, urine Female Humans Hypertension, Pregnancy-Induced / drug therapy*, urine Longitudinal Studies Pregnancy Pregnancy Complications, Cardiovascular / drug therapy*, urine Pregnancy Outcome Pregnancy, High-Risk Prostaglandins / metabolism Thromboxane A2 / analogs & derivatives, metabolism*, urine Thromboxane B2 / analogs & derivatives*, urine |
| Chemical | |
Reg. No./Substance:
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0/Cyclooxygenase Inhibitors; 0/Prostaglandins; 35121-78-9/Epoprostenol; 50-78-2/Aspirin; 54397-85-2/Thromboxane B2; 57576-52-0/Thromboxane A2; 58962-34-8/6-Ketoprostaglandin F1 alpha; 64700-71-6/2,3-dinor-6-ketoprostaglandin F1alpha; 67910-12-7/11-dehydro-thromboxane B2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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