Document Detail

Prostacyclin, thromboxane A2, and hypertension.
MedLine Citation:
PMID:  2078914     Owner:  NLM     Status:  MEDLINE    
Prostacyclin and thromboxane A2, products of separate branches of the arachidonic acid cascade, can have opposing effects on kidney function and on the vascular musculature. Prostacyclin acts as a vasodilator while thromboxane A2 has a vasoconstrictor effect and the balance between these two compounds appears to contribute to the homeostatic regulation of normal blood pressure. In the hypertensive state, this balance is disrupted and, at least in animal models of hypertension, there is excessive production of both. The increase in prostacyclin formation may be a reaction to the elevated blood pressure, possibly due to mechanical stimulation of the vascular smooth muscle cells in the blood vessel wall. However, the increase in thromboxane A2 may be more directly involved in the development and maintenance of hypertension. Not only is thromboxane A2 a vasoconstrictor but it can also stimulate the growth and proliferation of vascular smooth muscle cells which may account for the vascular hypertrophy seen in hypertension. Both of these actions would increase total peripheral resistance and contribute to hypertension. Whether prostacyclin and thromboxane A2 are in fact involved as causative agents in essential hypertension must await future research.
W G Zhao; J S Richardson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinical and investigative medicine. Médecine clinique et experimentale     Volume:  13     ISSN:  0147-958X     ISO Abbreviation:  Clin Invest Med     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-04-26     Completed Date:  1991-04-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7804071     Medline TA:  Clin Invest Med     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  343-52     Citation Subset:  IM    
Department of Neurology, Shandong Medical University, People's Republic of China.
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MeSH Terms
Epoprostenol / physiology*
Hypertension / etiology,  physiopathology*
Thromboxane A2 / physiology*
Vasomotor System / physiology
Reg. No./Substance:
35121-78-9/Epoprostenol; 57576-52-0/Thromboxane A2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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