| Prostacyclin therapy for pulmonary arterial hypertension: new directions. | |
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MedLine Citation:
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PMID: 16121316 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pulmonary arterial hypertension (PAH) is characterized by vasoconstriction and smooth muscle cell proliferation of the pulmonary arterioles, as well as in situ thrombosis of the small pulmonary arteries. Prostacyclin is involved in PAH vascular remodeling. It is unclear if decreased prostacyclin in the lungs is a cause or a consequence of PAH, but the relative lack of prostacyclin and its positive effects on the pulmonary vascular bed support the theory that long-term prostacyclin replacement is effective. Current therapies based on evidence-based medicine include epoprostenol, treprostinil, iloprost, and beraprost, each with limitations based on the drugs' inherent properties and administration route. Treatment of PAH by inhibiting multiple pathways concurrently may produce additive benefit. Because prostacyclin therapy is not curative and does not normalize pulmonary hemodynamics in the majority of cases, combining a prostacyclin with other PAH agents may be a promising approach. |
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Authors:
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Mardi Gomberg-Maitland; Ioana R Preston |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in respiratory and critical care medicine Volume: 26 ISSN: 1069-3424 ISO Abbreviation: Semin Respir Crit Care Med Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-08-25 Completed Date: 2006-01-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9431858 Medline TA: Semin Respir Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 394-401 Citation Subset: IM |
Affiliation:
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Division of Cardiology, University of Chicago Hospitals, IL 60637, USA. mgomberg@medicine.bsd.uchicago.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antihypertensive Agents
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therapeutic use* Clinical Trials as Topic Drug Therapy, Combination Epoprostenol / analogs & derivatives, therapeutic use* Humans Hypertension, Pulmonary / drug therapy* Iloprost / therapeutic use Vasodilator Agents / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Vasodilator Agents; 0/treprostinil; 35121-78-9/Epoprostenol; 78919-13-8/Iloprost; 88430-50-6/beraprost |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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