| Prostacyclin synthesis in relation to sympathoadrenal activation. Effects of beta-blockade. | |
MedLine Citation:
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PMID: 1683609 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Results from several studies suggest that beta-adrenoceptor blockade causes increased biosynthesis of the vasodilator prostanoid prostacyclin in the arterial wall. This effect may contribute to the clinical effects of beta-blockers in hypertension and coronary heart disease. Studies in hypertensive patients and in animals indicate that the arterial pressure reduction after beta-blockade is related to the associated increase of prostacyclin biosynthesis, regarding both magnitude and time of onset of effect. Some observations suggest that the effects of beta-blockers in myocardial ischemia may in part be due to an improvement of coronary blood flow caused by increased prostacyclin biosynthesis. |
Authors:
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K Pettersson; G Hansson; J A Björkman; B Ablad |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Circulation Volume: 84 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1991 Dec |
Date Detail:
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Created Date: 1992-01-07 Completed Date: 1992-01-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: VI38-43 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiovascular Pharmacology, Astra Hässle AB, Mölndal, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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pharmacology* Animals Antihypertensive Agents / pharmacology Epoprostenol / biosynthesis* Humans Sympathetic Nervous System / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Antihypertensive Agents; 35121-78-9/Epoprostenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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