Document Detail

Prostacyclin prevents hyperacute xenogenous rejection of the kidney.
MedLine Citation:
PMID:  3125022     Owner:  NLM     Status:  MEDLINE    
The rabbit kidney, perfused under a constant pressure from the canine femoral artery is rejected (i.e. blood flow arrests) within several minutes. It cannot be prevented by intraarterial infusion of strong vasodilatators, such as verapamil and prostaglandin E2. Prostacyclin PGI2 infusion is capable of maintaining a sufficient blood flow and urine production in the rabbit kidney as long as the infusion continues. Once the infusion is interrupted, signs of hyperacute rejection immediately appear. PGI2 or its analogue with a prolonged halflife seem promisive in the treatment of the transplanted kidney rejection.
J Heller; V Horácek
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Czechoslovak medicine     Volume:  10     ISSN:  0139-9179     ISO Abbreviation:  Czech Med     Publication Date:  1987  
Date Detail:
Created Date:  1988-04-07     Completed Date:  1988-04-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7805372     Medline TA:  Czech Med     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  195-200     Citation Subset:  IM    
Institute for Clinical and Experimental Medicine, Prague.
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MeSH Terms
Epoprostenol / pharmacology*
Graft Rejection / drug effects*
Heparin / therapeutic use
Kidney Transplantation*
Prostaglandins E / therapeutic use*
Prostaglandins E, Synthetic / pharmacology*
Transplantation, Heterologous
Verapamil / therapeutic use
Reg. No./Substance:
0/Prostaglandins E; 0/Prostaglandins E, Synthetic; 35121-78-9/Epoprostenol; 363-24-6/Dinoprostone; 52-53-9/Verapamil; 9005-49-6/Heparin

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