Document Detail

Prostacyclin-like activity in umbilical arteries is dose-dependently reduced by maternal smoking and related to nicotine levels.
MedLine Citation:
PMID:  2076446     Owner:  NLM     Status:  MEDLINE    
The influence of maternal smoking on the formation of prostacyclin-like activity in human umbilical arteries was studied in 84 unselected term deliveries. In arteries from infants of nonsmoking mothers the prostacyclin-like activity measured by a bioassay technique amounted to 81 +/- 37 ng/g (mean +/- SD), and in those from smokers to 67 +/- 35 ng/g (p less than 0.05). When smokers were divided into those smoking 10 cigarettes daily or more and those smoking 1-9 cigarettes per day, only arteries of infants of the heavier smokers showed a significantly reduced prostacyclin-like activity (56 +/- 27 ng/g; p less than 0.02). Nicotine and cotinine levels were weakly inversely correlated to prostacyclin-like activity (p less than 0.05). Reduced prostacyclin production in umbilical arteries implies reduced capacity for vasodilation and lowered defence against fetal hypoxia in heavy smokers.
G Ahlsten; U Ewald; T Tuvemo
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biology of the neonate     Volume:  58     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1990  
Date Detail:
Created Date:  1991-04-22     Completed Date:  1991-04-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  271-8     Citation Subset:  IM    
Department of Pediatrics, University Hospital, Uppsala, Sweden.
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MeSH Terms
Adenosine Diphosphate / pharmacology
Cotinine / blood
Epoprostenol / biosynthesis*,  blood,  pharmacology
Fetal Blood / chemistry
Infant, Newborn
Muscle, Smooth, Vascular / physiology
Nicotine / blood*
Platelet Aggregation / drug effects
Smoking / blood*
Umbilical Arteries / physiology*
Reg. No./Substance:
35121-78-9/Epoprostenol; 486-56-6/Cotinine; 54-11-5/Nicotine; 58-64-0/Adenosine Diphosphate

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