| Prostacyclin inhibits pancreatic secretion. | |
| | |
MedLine Citation:
|
PMID: 6155788 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Prostacyclin (PGI2), the major product of arachidonate metabolism in the gastrointestinal tract, was shown to affect gastric blood flow and gastric secretion, but it is unknown whether it also affects pancreatic secretion. This study was designed to determine the influence of PGI2 on pancreatic secretion under basal conditions and in response to exogenous and endogenous stimulants. PGI2 alone given in graded intravenous doses caused a slight pancreatic bicarbonate and protein secretion in fasted dogs. When given during stimulated pancreatic secretion, PGI2 caused a potent inhibition of the bicarbonate and protein secretion induced by feeding a liver meal, by duodenal perfusion with hydrochloric acid or amino acid mixture, and by intravenous infusion of secretin or caerulein. The kinetic analysis showed that the interaction between PGI2 and secretin affecting bicarbonate secretion is of a mixed type (increased half-maximal dose response, decreased calculated maximal response). This indicates that PGI2 decreases both the total secretory capacity of the pancreas to secrete bicarbonate and reduces the sensitivity of the pancreatic secretory cells to secretin. Because PGI2 significantly reduced the arterial blood pressure, its inhibitory effects on pancreatic secretion could be due, at least in part, to the interference of the blood flow to the pancreas. |
| | |
Authors:
|
S J Konturek; J Tasler; J Jaworek; M Cieszkowski; W Pawlik |
Related Documents
:
|
19501998 - Hepatic perfusion changes in an experimental model of acute pancreatitis: evaluation by... 631638 - Exocrine pancreatic secretion and immunoreactive secretin (irs) release after intraduod... 22427518 - Suppression of trophoblast uterine spiral artery remodeling by estrogen during baboon p... 16210958 - Validation of large particle flow cytometry for the analysis and sorting of intact panc... 16244068 - Further observations on the blood parasites of birds in uganda. 99808 - Lead poisoning treated with haemodialysis. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The American journal of physiology Volume: 238 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1980 Jun |
Date Detail:
|
Created Date: 1980-08-28 Completed Date: 1980-08-28 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: G531-6 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amylases
/
secretion Animals Bicarbonates / secretion Blood Pressure / drug effects Caerulein / pharmacology* Dogs Dose-Response Relationship, Drug Drug Synergism Epoprostenol / pharmacology* Heart Rate / drug effects Pancreas / secretion* Prostaglandins / pharmacology* Secretin / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Bicarbonates; 0/Prostaglandins; 1393-25-5/Secretin; 17650-98-5/Caerulein; 35121-78-9/Epoprostenol; EC 3.2.1.-/Amylases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of glucocorticoids on muscle protein turnover in perfused rat hemicorpus.
Next Document: Palliative management of esophageal carcinoma.