| Prostacyclin in the intensive care setting. | |
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MedLine Citation:
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PMID: 20216163 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The prostacyclins-prostanoids were one of the first medications used to treat pulmonary arterial hypertension (PAH). Three prostanoids have been developed to treat PAH: epoprostenol, treprostinil, and iloprost. In the acute setting, experience is growing, using the inhaled forms of these three medications. Inhalation may improve ventilation/perfusion matching, whereas in the intravenous form these medications may cause nonselective pulmonary vasodilation and may worsen ventilation/perfusion matching. Currently, there are no universal recommendations for dosing delivery of inhaled prostanoids to intubated patients in the intensive care unit setting. |
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Authors:
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D Dunbar Ivy |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies Volume: 11 ISSN: 1529-7535 ISO Abbreviation: Pediatr Crit Care Med Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-10 Completed Date: 2010-06-14 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 100954653 Medline TA: Pediatr Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: S41-5 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of Colorado Denver School of Medicine, The Children's Hospital, Aurora, CO, USA. ivy.dunbar@tchden.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Antihypertensive Agents / administration & dosage, therapeutic use* Child Epoprostenol / administration & dosage, analogs & derivatives, therapeutic use Humans Hypertension, Pulmonary / drug therapy* Iloprost / administration & dosage, therapeutic use Intensive Care* |
| Grant Support | |
ID/Acronym/Agency:
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P50 HL084923-04/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/treprostinil; 35121-78-9/Epoprostenol; 78919-13-8/Iloprost |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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