Document Detail

Prostacyclin-dependent coronary vasodilation in rabbit and guinea pig hearts.
MedLine Citation:
PMID:  380266     Owner:  NLM     Status:  MEDLINE    
Isolated hearts from rabbits or guinea pigs were perfused according to Langendorff and the coronary flow was recorded continuously. In addition, the rabbit heart transmyocardial effluent's content of platelet anti-aggregatory (prostacyclin-like, PCLA) activity was assayed biologically at regular intervals. Perfusion was performed with a solution gassed with 95% O2 in CO2, switching at intervals to a solution gassed with 12% O2 and 5% CO2 in N2. Perfusion with a hypoxic solution elicited reproducible increased in coronary flow. After pretreatment with indomethacin (5 x 10-5M), this increase was completely abolished and in several cases it was reversed to a marked reduction in cornonary flow. The transmyocardial effluent contained, during perfusion with normoxic solution, no detectable or only negligible amounts of PCLA. During hypoxia the efflux of PCAL into the transmyocardial effluent increased markedly. This increase was completely abolished when indomethacin (5 x 10-5M) was added to the solution perfusing the heart. The results strongly suggest that increased coronary vascular formation of prostacyclin plays a key role in the coronary vasodilation induced by hypoxia in rabbit and guinea pig hearts.
A Wennmalm
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  106     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1979 May 
Date Detail:
Created Date:  1979-09-27     Completed Date:  1979-09-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  47-52     Citation Subset:  IM    
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MeSH Terms
Adenosine Diphosphate / pharmacology
Anoxia / metabolism,  physiopathology*
Coronary Circulation* / drug effects
Epoprostenol / biosynthesis,  physiology*
Heart / physiology
Indomethacin / pharmacology
Myocardium / metabolism*
Platelet Aggregation / drug effects
Prostaglandins / physiology*
Vasodilation* / drug effects
Reg. No./Substance:
0/Prostaglandins; 35121-78-9/Epoprostenol; 53-86-1/Indomethacin; 58-64-0/Adenosine Diphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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