| Prospects for immunisation against Marburg and Ebola viruses. | |
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MedLine Citation:
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PMID: 20658513 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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For more than 30 years the filoviruses, Marburg virus and Ebola virus, have been associated with periodic outbreaks of hemorrhagic fever that produce severe and often fatal disease. The filoviruses are endemic primarily in resource-poor regions in Central Africa and are also potential agents of bioterrorism. Although no vaccines or antiviral drugs for Marburg or Ebola are currently available, remarkable progress has been made over the last decade in developing candidate preventive vaccines against filoviruses in nonhuman primate models. Due to the generally remote locations of filovirus outbreaks, a single-injection vaccine is desirable. Among the prospective vaccines that have shown efficacy in nonhuman primate models of filoviral hemorrhagic fever, two candidates, one based on a replication-defective adenovirus serotype 5 and the other on a recombinant VSV (rVSV), were shown to provide complete protection to nonhuman primates when administered as a single injection. The rVSV-based vaccine has also shown utility when administered for postexposure prophylaxis against filovirus infections. A VSV-based Ebola vaccine was recently used to manage a potential laboratory exposure. |
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Authors:
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Thomas W Geisbert; Daniel G Bausch; Heinz Feldmann |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Reviews in medical virology Volume: 20 ISSN: 1099-1654 ISO Abbreviation: Rev. Med. Virol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-27 Completed Date: 2011-01-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9112448 Medline TA: Rev Med Virol Country: England |
Other Details:
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Languages: eng Pagination: 344-57 Citation Subset: IM |
Copyright Information:
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2010 John Wiley & Sons, Ltd. |
Affiliation:
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Galveston National Laboratory1 and Department of Microbiology and Immunology2, University of Texas Medical Branch, 301 University Blvd., Galveston, TX, USA. twgeisbe@utmb.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenoviridae
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genetics Animals Disease Models, Animal Ebolavirus / immunology* Genetic Vectors Hemorrhagic Fever, Ebola / epidemiology, prevention & control* Humans Marburg Virus Disease / epidemiology, prevention & control* Marburgvirus / immunology* Primates Vaccination / methods Vaccines, Synthetic / immunology Vesiculovirus / genetics Viral Vaccines / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Vaccines, Synthetic; 0/Viral Vaccines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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