Document Detail


Prospects for adenovirus antivirals.
MedLine Citation:
PMID:  15743895     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adenoviruses cause a number of self-limiting but often highly infectious diseases that affect multiple organs, most commonly those associated with respiratory, genitourinary and gastrointestinal tracts and the ocular surface. Many factors have driven a search for effective topical and systemic antivirals to adenoviruses. These include patient morbidity, economic losses and chronic visual disturbances associated with epidemic keratoconjunctivitis; and the startling recent trend of high morbidity and rising mortality associated with systemic adenoviral infections in the immunosuppressed, particularly paediatric bone marrow transplant recipients. The development of effective antivirals has proven to be a complex task, owing to the fact that multiple and often genetically divergent adenovirus serotypes can cause similar diseases. Currently, there remains no licensed systemic or topical treatment in the USA or Europe. However, many compounds have been explored for activity against adenoviruses, and some have been evaluated clinically in either a topical setting for ocular disease or in the setting of systemic treatment in the face of life-threatening adenovirus infections. This article outlines such compounds, discusses the potential for their clinical development, and highlights some problems that may be faced in evaluating their efficacy clinically.
Authors:
Paul R Kinchington; Eric G Romanowski; Y Jerold Gordon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review     Date:  2005-03-02
Journal Detail:
Title:  The Journal of antimicrobial chemotherapy     Volume:  55     ISSN:  0305-7453     ISO Abbreviation:  J. Antimicrob. Chemother.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-25     Completed Date:  2005-05-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7513617     Medline TA:  J Antimicrob Chemother     Country:  England    
Other Details:
Languages:  eng     Pagination:  424-9     Citation Subset:  IM    
Affiliation:
Ophthalmology and Visual Sciences Research Centre, University of Pittsburgh, Pittsburgh, PA, USA. Kinchingtonp@upmc.edu
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MeSH Terms
Descriptor/Qualifier:
Adenovirus Infections, Human / drug therapy*,  physiopathology
Animals
Antiviral Agents / adverse effects,  therapeutic use*
Disease Models, Animal
Humans
Grant Support
ID/Acronym/Agency:
EY08098/EY/NEI NIH HHS; EY08227/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Antiviral Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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