Document Detail

Prospects for Interferon-Free Treatment of Hepatitis C.
MedLine Citation:
PMID:  23137126     Owner:  NLM     Status:  Publisher    
Present interferon-based therapy for chronic hepatitis C (CHC) is limited by both efficacy and tolerability. Telaprevir and boceprevir are the first two direct acting antiviral drugs (DAAs) which inhibit HCV replication to be licensed for use, in conjunction with pegylated interferon and ribavirin. Numerous other DAAs are in clinical development, and phase 2 and 3 trials are evaluating interferon-free combination DAA therapy. Interferon-free sustained virological responses (SVR) have now been achieved with combinations of asunaprevir and daclatasvir, sofosbuvir and ribavirin, sofosbuvir and daclatasvir, faldaprevir and BI207127, ABT-450, ritonovir and ABT-333, ABT-450, ritonovir and ABT-072, miracitabine, danoprevir and ritonavir, and alisporivir and ribavirin. Some drugs are genotype-specific in their activity, whereas others are pan-genotypic, and differential responses for the genotype 1 subtypes 1a and 1b have emerged with many DAA combinations. Viral breakthrough and resistance are important considerations for future trial design. The prospect of interferon-free combination DAA therapy for HCV is now finally becoming a reality.
Catherine A M Stedman
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-9
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  -     ISSN:  1440-1746     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.
Gastroenterologist and Hepatologist/Clinical Pharmacologist, Christchurch Hospital, Private Bag 4710, Christchurch, 8140, New Zealand.
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