| Prospects of Induced Pluripotent Stem (iPS) Cell Technology in Regenerative Medicine. | |
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MedLine Citation:
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PMID: 21210760 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Induced pluripotent stem (iPS) cells are derived from adult somatic cells via reprogramming with ectopic expression of four transcription factors (Oct3/4, Sox2, c-Myc and Klf4; or, Oct3/4, Sox2, Nanog and Lin28), by which the resultant cells regain pluripotency, namely, the capability exclusively possessed by some embryonic cells to differentiate into any cell lineage under proper conditions. Given the ease in cell sourcing and a waiver of ethical opponency, iPS cells excel embryonic pluripotent cells in the practice of drug discovery and regenerative medicine. With an ex vivo practice in regenerative medicine, many problems involved in conventional medicine dosing, such as immune rejection, could be potentially circumvented. In this article, we briefly summarize the fundamentals and status quo of iPS related applications, and emphasize the prospects of iPS technology in regenerative medicine. |
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Authors:
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Feng Zhang; Fudiman Citra; Dong-An Wang |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-7 |
Journal Detail:
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Title: Tissue engineering. Part B, Reviews Volume: - ISSN: 1937-3376 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101466660 Medline TA: Tissue Eng Part B Rev Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Singapore, Singapore; LIVEZHAN0176@e.ntu.edu.sg. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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