Document Detail


Prospective validation of the ICH Score for 12-month functional outcome.
MedLine Citation:
PMID:  19726752     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The ICH Score is a commonly used clinical grading scale for outcome after acute intracerebral hemorrhage (ICH) and has been validated for 30-day mortality, but not long-term functional outcome. The goals of this study were to assess whether the ICH Score accurately stratifies patients with regard to 12-month functional outcome and to further delineate the pace of recovery of patients during the first year post-ICH.
METHODS: We performed a prospective observational cohort study of all patients with acute ICH admitted to the emergency departments of San Francisco General Hospital and UCSF Medical Center from June 1, 2001, through May 31, 2004. Components of the ICH Score (admission Glasgow Coma Scale score, initial hematoma volume, presence of intraventricular hemorrhage, infratentorial ICH origin, and age) were recorded along with other clinical characteristics. Patients were then assessed with the modified Rankin Scale (mRS) at hospital discharge, 30 days, and 3, 6, and 12 months post-ICH.
RESULTS: Of 243 patients, 95 (39%) died during initial acute hospitalization. The ICH Score accurately stratified patients with regard to 12-month functional outcome for various dichotomous cutpoints along the mRS (p < 0.05). Many patients continued to improve across the first year, with a small number of patients becoming disabled or dying due to late events unrelated to the initial ICH.
CONCLUSIONS: The ICH Score is a valid clinical grading scale for long-term functional outcome after acute intracerebral hemorrhage (ICH). Many ICH patients improve after hospital discharge and this improvement may continue even after 6 months post-ICH.
Authors:
J Claude Hemphill; Mary Farrant; Terry A Neill
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Validation Studies     Date:  2009-09-02
Journal Detail:
Title:  Neurology     Volume:  73     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-06     Completed Date:  2009-10-30     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1088-94     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurology, University of California, San Francisco, USA. chemphill@sfgh.ucsf.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Cerebral Hemorrhage / complications*,  physiopathology*
Female
Humans
Male
Middle Aged
Observer Variation
Predictive Value of Tests
Prognosis
Prospective Studies
Recovery of Function
Research Design
Severity of Illness Index
Stroke / etiology*,  physiopathology*
Time Factors
Grant Support
ID/Acronym/Agency:
K23 NS41240/NS/NINDS NIH HHS
Comments/Corrections
Comment In:
Neurology. 2009 Oct 6;73(14):1084-5   [PMID:  19726749 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Follow-up of [11C]PIB uptake and brain volume in patients with Alzheimer disease and controls.
Next Document:  Replication of prostate cancer risk loci in a Japanese case-control association study.