Document Detail

Prospective trial on obstructive sleep apnea in pregnancy and fetal heart rate monitoring.
MedLine Citation:
PMID:  20171603     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Obstructive sleep apnea (OSA) involves episodic nocturnal apneas. Using polysomnography, we examined the predictive capacity of screening questionnaires (Berlin) in pregnancy. Incorporating simultaneous fetal heart rate monitoring (FHM), we examined the association of maternal apnea with FHM abnormalities. STUDY DESIGN: We enrolled 100 pregnant women at 26-39 weeks of gestation with OSA screening and baseline data ascertainment who underwent polysomnography and FHM for > or =3 hours. The relationship between maternal characteristics, OSA, and FHM was explored with multivariate analyses that were controlled for potential confounders. RESULTS: When compared with polysomnography, sensitivity and specificity by Berlin screening was 35% and 63.8%, respectively; the snoring component of the Berlin correlated better with oxygen desaturation <95% (P = .003). Body mass index was a significant confounder (r(s) = 0.44; P < .0001). No association was observed between FHM abnormalities and OSA parameters. CONCLUSION: In pregnancy, the Berlin questionnaire poorly predicts OSA. It is unclear whether fetal compromise during maternal apnea is a mechanism in OSA that is related to pregnancy outcome.
Sofia A Olivarez; Bani Maheshwari; Meghan McCarthy; Nikolaos Zacharias; Ignatia van den Veyver; Lata Casturi; Haleh Sangi-Haghpeykar; Kjersti Aagaard-Tillery
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Publication Detail:
Type:  Journal Article     Date:  2010-02-20
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  202     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-31     Completed Date:  2010-06-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  552.e1-7     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010 Mosby, Inc. All rights reserved.
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine, Ben Taub General Hospital, Houston, TX, USA.
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MeSH Terms
Body Mass Index
Heart Rate, Fetal
Multivariate Analysis
Patient Selection
Pregnancy Complications / diagnosis*
Prospective Studies
Sensitivity and Specificity
Sleep Apnea, Obstructive / diagnosis*

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