Document Detail


Prospective surveillance study of severe hyperbilirubinaemia in the newborn in the UK and Ireland.
MedLine Citation:
PMID:  17074786     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To determine the incidence of severe hyperbilirubinaemia in the newborn, and to identify associated clinical and demographic variables, and short-term outcomes.
DESIGN: Prospective, population-based study.
SETTING: UK and Republic of Ireland, between 1 May 2003 and 31 May 2005.
PARTICIPANTS: Infants in the first month of life with severe hyperbilirubinaemia (maximum unconjugated serum bilirubin >/=510 micromol/l).
RESULTS: 108 infants met the case definition, 106 from the UK and 2 from the Republic of Ireland. The UK incidence of severe hyperbilirubinaemia was 7.1/100 000 live births (95% CI 5.8 to 8.6). Only 20 cases presented in hospital; 88 were admitted with severe jaundice. 64 (60.4%) cases were male, and 56 (51.8%) were of ethnic minority origin. 87 (80.5%) cases were exclusively breast fed. Co-morbidity included haemolysis, dehydration, infection and bruising. 14 infants showed evidence of bilirubin encephalopathy, of whom 3 died. The UK incidence of bilirubin encephalopathy was 0.9/100 000 live births (95% CI 0.46 to 1.5).
CONCLUSIONS: This is the first large, prospective, population-based study of the incidence of severe hyperbilirubinaemia in the newborn. The clinical and demographic associations, and short-term outcomes identified, are the same as those reported recently in North America and Europe.
Authors:
Donal Manning; Peter Todd; Melanie Maxwell; Mary Jane Platt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-10-30
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  92     ISSN:  1359-2998     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-22     Completed Date:  2007-10-04     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  England    
Other Details:
Languages:  eng     Pagination:  F342-6     Citation Subset:  AIM; IM    
Affiliation:
Donal Manning, Department of Paediatrics, Arrowe Park Hospital, Wirral, Merseyside CH49 5PE, UK. donal.manning@whnt.nhs.uk
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MeSH Terms
Descriptor/Qualifier:
Bilirubin / blood
Blood Transfusion / methods
Female
Great Britain / epidemiology
Hospitalization
Humans
Hyperbilirubinemia / blood,  epidemiology*,  therapy
Incidence
Infant, Newborn
Ireland / epidemiology
Jaundice, Neonatal / blood,  epidemiology,  therapy
Kernicterus / blood,  epidemiology,  therapy
Male
Population Surveillance / methods
Prognosis
Prospective Studies
Risk Factors
Sex Distribution
Chemical
Reg. No./Substance:
635-65-4/Bilirubin
Comments/Corrections
Comment In:
Arch Dis Child Fetal Neonatal Ed. 2007 Sep;92(5):F330-1   [PMID:  17712180 ]

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