Document Detail

Prospective study of suspected associations between certain drugs administered during early pregnancy and congenital malformations.
MedLine Citation:
PMID:  6845218     Owner:  NLM     Status:  MEDLINE    
From 1964 to 1976, a cohort study was performed in West Germany to study the possible influence of various factors on pregnancy and child development. Results of the evaluation of 13,643 pregnancies are given with respect to possible teratogenetic effects of antiemetic drugs and sex hormones administered in early pregnancy. There was no evidence of an increased risk of major malformations following the intake of certain antiemetic drugs and progesterone. Also, the use of a hormonal pregnancy test was not significantly associated with an increase of major malformations.
J Michaelis; H Michaelis; E Glück; S Koller
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Teratology     Volume:  27     ISSN:  0040-3709     ISO Abbreviation:  Teratology     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-06-10     Completed Date:  1983-06-10     Revised Date:  2010-07-15    
Medline Journal Info:
Nlm Unique ID:  0153257     Medline TA:  Teratology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  57-64     Citation Subset:  IM    
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MeSH Terms
Abnormalities, Drug-Induced / epidemiology*
Antiemetics / adverse effects
Doxylamine / adverse effects
Drug Combinations / adverse effects
Estradiol / adverse effects,  analogs & derivatives
Germany, West
Progesterone / adverse effects
Prospective Studies
Pyridoxine / adverse effects
Time Factors
Reg. No./Substance:
0/Antiemetics; 0/Drug Combinations; 0/dicyclomine, doxylamine, pyridoxine drug combination; 469-21-6/Doxylamine; 50-28-2/Estradiol; 57-83-0/Progesterone; 65-23-6/Pyridoxine; 8000-03-1/Duogynon forte

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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