Document Detail


Prospective study of presynaptic dopaminergic imaging in patients with mild parkinsonism and tremor disorders: part 1. Baseline and 3-month observations.
MedLine Citation:
PMID:  14502664     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To record prospectively, from early presentation, the clinical features of parkinsonism and tremor disorders, in relation to evidence of dopaminergic deficit shown with [(123)I]-FP-CIT (DaTSCAN, Amersham Health) single photon emission computerised tomography (SPECT). Clinical signs were recorded in 62 patients, of whom 24 failed standard Parkinson's disease (PD) and essential tremor criteria, and 38 fulfilled UK Brain Bank step 1 PD criteria. Striatal radioligand uptake was graded visually as normal or abnormal, and specific:nonspecific ratios were calculated. Bradykinesia and rigidity showed significant overall association with abnormal scans (P < or = 0.003), but rest tremor did not (P = NS). In the 24 patients not fulfilling specific criteria (mean age 63 [SD 9] years, disease duration 3 [SD 4] years), 10 (42%) had abnormal visual SPECT assessment and 14 (58%) had normal scans. Of 38 patients with early PD by clinical criteria (mean age 60 [SD 9] years, disease duration 3 [SD 1.7] years), 33 (87%) were visually abnormal. Baseline clinical diagnosis corresponded with SPECT imaging results in 51 of 62 cases (82%), which increased to 56 of 62 cases (90%) with amendment of seven clinical diagnoses at 3 months (blind to SPECT results). Akinetic-rigid cardinal diagnostic features of parkinsonism associate well with dopaminergic deficit in patients with early and mild clinical features. When these clinical features are uncertain, or the patient fails clinical diagnostic criteria, testing for dopaminergic deficit with [(123)I]-FP-CIT SPECT may assist the diagnostic process.
Authors:
Hani T S Benamer; Wolfgang H Oertel; Jim Patterson; Donald M Hadley; Oliver Pogarell; H Höffken; A Gerstner; Donald G Grosset
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  18     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-22     Completed Date:  2004-01-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  977-84     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Movement Disorder Society
Affiliation:
Neurology Department, New Cross Hospital, Wolverhampton, United Kingdom. benamer@doctors.org.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Corpus Striatum / metabolism*,  radiography
Dopamine / deficiency*
Dopamine Plasma Membrane Transport Proteins
Essential Tremor / metabolism*,  radionuclide imaging
Female
Humans
Iodine Isotopes / diagnostic use
Male
Membrane Glycoproteins*
Membrane Transport Proteins
Middle Aged
Nerve Tissue Proteins*
Nortropanes / diagnostic use
Parkinson Disease / metabolism*,  radionuclide imaging
Severity of Illness Index
Time Factors
Tomography, Emission-Computed, Single-Photon
Tropanes*
Chemical
Reg. No./Substance:
0/Dopamine Plasma Membrane Transport Proteins; 0/Iodine Isotopes; 0/Membrane Glycoproteins; 0/Membrane Transport Proteins; 0/Nerve Tissue Proteins; 0/Nortropanes; 0/Tropanes; 155797-99-2/2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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