Document Detail

Prospective study of mother-to-infant transmission of hepatitis C virus: a 10-year survey (1990-2000).
MedLine Citation:
PMID:  12694118     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The purpose of this study was to determine the rate of vertical transmission of hepatitis C virus (HCV). We also aimed to analyze the time of clearance of maternal antibodies in the serum of non-infected babies. METHODS: Between March 1990 and March 2000, 170 consecutive anti-HCV-positive women and their 188 babies entered this prospective study. All women were analyzed for HCV-RNA using polymerase chain reaction (PCR). The babies were followed-up until HCV-antibody clearance or until the diagnosis of HCV infection. RESULTS: The vertical transmission rate was 2.7% overall, and it was higher in HIV co-infected women (5.4%, 2/37) than in HIV-negative women (2.0%, 3/151). All infected infants were born to mothers who had HCV viremia at delivery. The transmission rate was influenced by maternal levels of viremia. 37.2% of uninfected children became HCV-antibody negative by 6 months and 88.0% by 12 months. Babies born from HCV-RNA-positive mothers lost anti-HCV antibodies later (9.21 +/- 3.72 months) than babies born from HCV-RNA-negative mothers (7.47 +/- 3.46 months) ( p < 0.05, Kolmogorov-Smirnov test). CONCLUSIONS: The risk of HCV vertical transmission is very low in HCV-positive/HIV-negative women and it is restricted to infants born to HCV viremic mothers. High maternal viral load is predictive of the vertical transmission. The clearance time of antibodies in non-infected babies is significantly longer if the mother is viremic.
Simone Ferrero; Pietro Lungaro; Bianca Marisa Bruzzone; Cristina Gotta; Giorgio Bentivoglio; Nicola Ragni
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  82     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-04-15     Completed Date:  2003-05-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  229-34     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Genoa, Genoa, Italy.
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MeSH Terms
HIV / growth & development
HIV Infections / complications
Hepacivirus / growth & development*
Hepatitis C / blood,  complications,  epidemiology,  transmission*
Hepatitis C Antibodies / blood*
Infant, Newborn
Infectious Disease Transmission, Vertical / prevention & control*
Italy / epidemiology
Polymerase Chain Reaction
Pregnancy Complications, Infectious / blood,  virology*
Prospective Studies
RNA, Viral / isolation & purification
Seroepidemiologic Studies
Viremia / epidemiology,  transmission
Reg. No./Substance:
0/Hepatitis C Antibodies; 0/RNA, Viral

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