Document Detail


Prospective study of moderate alcohol consumption and risk of peripheral arterial disease in US male physicians.
MedLine Citation:
PMID:  9024142     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Moderate alcohol consumption decreases the risk of coronary heart disease, but its relation to peripheral arterial disease (PAD) is uncertain. METHODS AND RESULTS: In the Physicians' Health Study, a randomized trial of the use of aspirin and beta-carotene in 22071 apparently healthy men, we documented 433 incident cases of PAD during 11 years of follow-up. After we controlled for age and treatment assignment, daily drinkers (> or = 7 drinks per week) had a relative risk (RR) of PAD of 0.92 (95% confidence interval, 0.72 to 1.17) compared with the reference group (< 1 drink per week). After additional control for smoking, however, the RR was 0.68 (0.52 to 0.89). Further control for exercise, diabetes mellitus, and parental history of myocardial infarction revealed an RR of 0.74 (0.57 to 0.97). CONCLUSIONS: Moderate alcohol consumption appears to decrease the risk of PAD in apparently healthy men.
Authors:
C A Camargo; M J Stampfer; R J Glynn; J M Gaziano; J E Manson; S Z Goldhaber; C H Hennekens
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  95     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-03-11     Completed Date:  1997-03-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  577-80     Citation Subset:  AIM; IM    
Affiliation:
Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215-1204, USA. camargoc@a1.mgh.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcohol Drinking*
Arteries
Aspirin / therapeutic use
Cardiovascular Diseases / prevention & control
Double-Blind Method
Humans
Incidence
Male
Middle Aged
Neoplasms / prevention & control
Physicians*
Prospective Studies
Risk Factors
United States
Vascular Diseases* / epidemiology
beta Carotene / therapeutic use
Grant Support
ID/Acronym/Agency:
CA-34944/CA/NCI NIH HHS; HL-26490/HL/NHLBI NIH HHS; HL-34595/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
50-78-2/Aspirin; 7235-40-7/beta Carotene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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