Document Detail


Prospective study of meat intake and dietary nitrates, nitrites, and nitrosamines and risk of adult glioma.
MedLine Citation:
PMID:  19587083     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The hypothesis that nitrosamine exposure may increase the risk of glioma has been circulating for several decades, but testing it has been difficult because of the ubiquitous nature of nitrosamine exposure. Diet has been the focus of many studies because it can substantially influence nitrosamine exposure, mostly from the endogenous formation of nitrosamines based on intake of nitrite and nitrate.
OBJECTIVE: The objective was to examine the relation between intakes of meats, nitrate, nitrite, and 2 nitrosamines [nitrosodimethylamine (NDMA) and nitrosopyrolidine (NPYR)] and glioma risk in a prospective analysis.
METHODS: Data from 3 US prospective cohort studies were combined for this analysis; 335 glioma cases were diagnosed during < or =24 y of follow-up. Dietary intake was assessed with food-frequency questionnaires. Nitrate, nitrite, and nitrosamine values were calculated based on published values of these nutrients in various foods over different periods in time. Cox proportional hazards models were used to estimate incidence rate ratios (RRs) and 95% CIs. Estimates from each cohort were pooled by using a random-effects model.
RESULTS: Risk of glioma was not elevated among individuals in the highest intake category of total processed meats (RR: 0.92; 95% CI: 0.48, 1.77), nitrate (RR: 1.02; 95% CI: 0.66, 1.58), nitrites (RR: 1.26; 95% CI: 0.89, 1.79), or NDMA (RR: 0.88; 95% CI: 0.57, 1.36) compared with the lowest category. No effect modification was observed by intake of vitamins C or E or other antioxidant measures.
CONCLUSION: We found no suggestion that intake of meat, nitrate, nitrite, or nitrosamines is related to the risk of glioma.
Authors:
Dominique S Michaud; Crystal N Holick; Tracy T Batchelor; Edward Giovannucci; David J Hunter
Related Documents :
6722053 - Genotoxic exposure of workers creosoting wood.
9202743 - Antigenotoxic activity of natural chlorophylls.
2872783 - A preliminary comparison of trypanosoma simiae and t. congolense by isoenzyme electroph...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-07-08
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  90     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-21     Completed Date:  2009-09-29     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  570-7     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Brain Neoplasms / epidemiology,  etiology*
Cohort Studies
Diet*
Diet Surveys
Dimethylnitrosamine / adverse effects*
Female
Glioma / epidemiology,  etiology*
Humans
Male
Meat / adverse effects*
Meat Products / adverse effects
Middle Aged
Nitrates / adverse effects*
Nitrites / adverse effects*
Nitrosamines / adverse effects*
Proportional Hazards Models
Risk
Grant Support
ID/Acronym/Agency:
CA110948/CA/NCI NIH HHS; R03 CA110948/CA/NCI NIH HHS; R03 CA110948-01A1/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Nitrates; 0/Nitrites; 0/Nitrosamines; M43H21IO8R/Dimethylnitrosamine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The effect of tissue culture on suture holding strength and degradation in canine tendon.
Next Document:  Activation of the gut-brain axis by dietary glutamate and physiologic significance in energy homeost...