Document Detail

Prospective study of meat intake and dietary nitrates, nitrites, and nitrosamines and risk of adult glioma.
MedLine Citation:
PMID:  19587083     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The hypothesis that nitrosamine exposure may increase the risk of glioma has been circulating for several decades, but testing it has been difficult because of the ubiquitous nature of nitrosamine exposure. Diet has been the focus of many studies because it can substantially influence nitrosamine exposure, mostly from the endogenous formation of nitrosamines based on intake of nitrite and nitrate.
OBJECTIVE: The objective was to examine the relation between intakes of meats, nitrate, nitrite, and 2 nitrosamines [nitrosodimethylamine (NDMA) and nitrosopyrolidine (NPYR)] and glioma risk in a prospective analysis.
METHODS: Data from 3 US prospective cohort studies were combined for this analysis; 335 glioma cases were diagnosed during < or =24 y of follow-up. Dietary intake was assessed with food-frequency questionnaires. Nitrate, nitrite, and nitrosamine values were calculated based on published values of these nutrients in various foods over different periods in time. Cox proportional hazards models were used to estimate incidence rate ratios (RRs) and 95% CIs. Estimates from each cohort were pooled by using a random-effects model.
RESULTS: Risk of glioma was not elevated among individuals in the highest intake category of total processed meats (RR: 0.92; 95% CI: 0.48, 1.77), nitrate (RR: 1.02; 95% CI: 0.66, 1.58), nitrites (RR: 1.26; 95% CI: 0.89, 1.79), or NDMA (RR: 0.88; 95% CI: 0.57, 1.36) compared with the lowest category. No effect modification was observed by intake of vitamins C or E or other antioxidant measures.
CONCLUSION: We found no suggestion that intake of meat, nitrate, nitrite, or nitrosamines is related to the risk of glioma.
Dominique S Michaud; Crystal N Holick; Tracy T Batchelor; Edward Giovannucci; David J Hunter
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-07-08
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  90     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-21     Completed Date:  2009-09-29     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  570-7     Citation Subset:  AIM; IM    
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MeSH Terms
Brain Neoplasms / epidemiology,  etiology*
Cohort Studies
Diet Surveys
Dimethylnitrosamine / adverse effects*
Glioma / epidemiology,  etiology*
Meat / adverse effects*
Meat Products / adverse effects
Middle Aged
Nitrates / adverse effects*
Nitrites / adverse effects*
Nitrosamines / adverse effects*
Proportional Hazards Models
Grant Support
CA110948/CA/NCI NIH HHS; R03 CA110948/CA/NCI NIH HHS; R03 CA110948-01A1/CA/NCI NIH HHS
Reg. No./Substance:
0/Nitrates; 0/Nitrites; 0/Nitrosamines; M43H21IO8R/Dimethylnitrosamine

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