Document Detail


Prospective study evaluating the predictability of need for retreatment with intravitreal ranibizumab for age-related macular degeneration.
MedLine Citation:
PMID:  22733165     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: To investigate the rhythm and predictability of the need for retreatment with intravitreal injections of ranibizumab for neovascular age-related macular degeneration (nAMD). METHODS: This prospective study enrolled 39 patients with treatment-naïve nAMD. After three loading doses of intravitreal ranibizumab, patients underwent an intensified follow-up for 12 months (initially weekly, then with stepwise increases to every 2 weeks and to monthly after each injection). Patients were retreated on an as-needed basis if any fluid or increased central retinal thickness (CRT) (>50μm) was found on spectral domain optical coherence tomography (OCT). Statistical analysis included patients who received at least two retreatments (five injections). RESULTS: A mean of 7.5 injections (range 0-12) were given between months 3 and 15. The mean visual acuity increased by 13.1 and 12.6 ETDRS letters at months 12 and 15 respectively. Two or more injection-retreatment intervals were found in 31 patients. The variability of their intra-individual intervals up to 14 weeks was small (SD 0-2.13 weeks), revealing a high regularity of the retreatment rhythm. The SD was correlated with the mean interval duration (r = 0.89, p < 0.001). The first interval was a good predictor of the following intervals (regression coefficient =0.81). One retreatment criterion was stable in 97 % of patients (cysts or subretinal fluid). CONCLUSION: The results of this study demonstrate a high intra-individual predictability of retreatment need with ranibizumab injections for nAMD. These findings may be helpful for developing individualized treatment plans for maintained suppression of disease activity with a minimum of injections and visits.
Authors:
Irmela Mantel; Angeliki Deli; Katia Iglesias; Aude Ambresin
Related Documents :
19756895 - The use of an improved intragastric balloon technique to reduce weight in pre-obese pat...
20838235 - Outcomes of treatment of argon plasma coagulation therapy in elderly or high-risk patie...
2305215 - Effect of gastrectomy with either roux-en-y or billroth ii anastomosis on small-intesti...
24162155 - Digital templating in total knee and hip replacement: an analysis of planning accuracy.
19561345 - A randomized prospective study comparing two flexible epidural catheters for labour ana...
16904025 - Efficacy of very high dose steroid treatment in a case of landau-kleffner syndrome.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-26
Journal Detail:
Title:  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie     Volume:  -     ISSN:  1435-702X     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8205248     Medline TA:  Graefes Arch Clin Exp Ophthalmol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Ophthalmology Department of the University of Lausanne, Jules-Gonin Eye Hospital, Lausanne, Switzerland, irmela.mantel@fa2.ch.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Mathematical modeling of maize starch liquefaction catalyzed by ?-amylases from Bacillus licheniform...
Next Document:  Novel Fragmentation Pathways of Anionic Adducts of Steroids Formed by Electrospray Anion Attachment ...