Document Detail


Prospective study of correlates of vaginal Lactobacillus colonisation among high-risk HIV-1 seronegative women.
MedLine Citation:
PMID:  19329442     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Vaginal colonisation with Lactobacillus species is characteristic of normal vaginal ecology. The absence of vaginal lactobacilli, particularly hydrogen peroxide (H(2)O(2))-producing isolates, has been associated with symptomatic bacterial vaginosis (BV) and increased risk for HIV-1 acquisition. Identification of factors associated with vaginal Lactobacillus colonisation may suggest interventions to improve vaginal health.
METHODS: We conducted a prospective cohort study of correlates of vaginal Lactobacillus colonisation among Kenyan HIV-1 seronegative female sex workers. At monthly follow-up visits, vaginal Lactobacillus cultures were obtained. Generalised estimating equations were used to examine demographic, behavioural and medical correlates of Lactobacillus isolation, including isolation of H(2)O(2)-producing strains.
RESULTS: Lactobacillus cultures were obtained from 1020 women who completed a total of 8896 follow-up visits. Vaginal washing, typically with water alone or with soap and water, was associated with an approximately 40% decreased likelihood of Lactobacillus isolation, including isolation of H(2)O(2)-producing strains. Recent antibiotic use, excluding metronidazole and treatments for vaginal candidiasis, reduced Lactobacillus isolation by approximately 30%. H(2)O(2)-producing lactobacilli were significantly less common among women with Trichomonas vaginalis infection and those who were seropositive for herpes simplex virus type 2. In contrast, H(2)O(2)-producing lactobacilli were significantly more common among women with concurrent vaginal candidiasis.
CONCLUSIONS: Modifiable biological and behavioural factors are associated with Lactobacillus colonisation in African women. Our results suggest intervention strategies to improve vaginal health in women at high risk for HIV-1.
Authors:
J M Baeten; W M Hassan; V Chohan; B A Richardson; K Mandaliya; J O Ndinya-Achola; W Jaoko; R S McClelland
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-03-26
Journal Detail:
Title:  Sexually transmitted infections     Volume:  85     ISSN:  1472-3263     ISO Abbreviation:  Sex Transm Infect     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-09-23     Completed Date:  2009-11-12     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  9805554     Medline TA:  Sex Transm Infect     Country:  England    
Other Details:
Languages:  eng     Pagination:  348-53     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-Bacterial Agents / administration & dosage,  adverse effects
Female
HIV Seronegativity*
HIV-1 / isolation & purification
Herpesvirus 2, Human / isolation & purification
Humans
Hydrogen Peroxide / metabolism
Kenya / epidemiology
Lactobacillus / isolation & purification*
Prospective Studies
Prostitution*
Risk Factors
Soaps / adverse effects
Trichomonas Vaginitis / complications
Vagina / microbiology*
Vaginal Douching / adverse effects
Vaginosis, Bacterial / epidemiology*
Young Adult
Grant Support
ID/Acronym/Agency:
D43-TW00007/TW/FIC NIH HHS; K23 AI052480-05/AI/NIAID NIH HHS; K23-AI52480/AI/NIAID NIH HHS; N01-A1-35173-119//PHS HHS; P30 AI027757/AI/NIAID NIH HHS; R01-AI33873/AI/NIAID NIH HHS; R01-AI38518/AI/NIAID NIH HHS; R01-AI52480/AI/NIAID NIH HHS; R37 AI038518/AI/NIAID NIH HHS; R37 AI038518-09/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Soaps; BBX060AN9V/Hydrogen Peroxide
Comments/Corrections

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