| Prospective study of correlates of vaginal Lactobacillus colonisation among high-risk HIV-1 seronegative women. | |
| | |
MedLine Citation:
|
PMID: 19329442 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Vaginal colonisation with Lactobacillus species is characteristic of normal vaginal ecology. The absence of vaginal lactobacilli, particularly hydrogen peroxide (H(2)O(2))-producing isolates, has been associated with symptomatic bacterial vaginosis (BV) and increased risk for HIV-1 acquisition. Identification of factors associated with vaginal Lactobacillus colonisation may suggest interventions to improve vaginal health. METHODS: We conducted a prospective cohort study of correlates of vaginal Lactobacillus colonisation among Kenyan HIV-1 seronegative female sex workers. At monthly follow-up visits, vaginal Lactobacillus cultures were obtained. Generalised estimating equations were used to examine demographic, behavioural and medical correlates of Lactobacillus isolation, including isolation of H(2)O(2)-producing strains. RESULTS: Lactobacillus cultures were obtained from 1020 women who completed a total of 8896 follow-up visits. Vaginal washing, typically with water alone or with soap and water, was associated with an approximately 40% decreased likelihood of Lactobacillus isolation, including isolation of H(2)O(2)-producing strains. Recent antibiotic use, excluding metronidazole and treatments for vaginal candidiasis, reduced Lactobacillus isolation by approximately 30%. H(2)O(2)-producing lactobacilli were significantly less common among women with Trichomonas vaginalis infection and those who were seropositive for herpes simplex virus type 2. In contrast, H(2)O(2)-producing lactobacilli were significantly more common among women with concurrent vaginal candidiasis. CONCLUSIONS: Modifiable biological and behavioural factors are associated with Lactobacillus colonisation in African women. Our results suggest intervention strategies to improve vaginal health in women at high risk for HIV-1. |
| | |
Authors:
|
J M Baeten; W M Hassan; V Chohan; B A Richardson; K Mandaliya; J O Ndinya-Achola; W Jaoko; R S McClelland |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-03-26 |
Journal Detail:
|
Title: Sexually transmitted infections Volume: 85 ISSN: 1472-3263 ISO Abbreviation: Sex Transm Infect Publication Date: 2009 Sep |
Date Detail:
|
Created Date: 2009-09-23 Completed Date: 2009-11-12 Revised Date: 2012-05-23 |
Medline Journal Info:
|
Nlm Unique ID: 9805554 Medline TA: Sex Transm Infect Country: England |
Other Details:
|
Languages: eng Pagination: 348-53 Citation Subset: IM |
Affiliation:
|
Department of Global Health, University of Washington, Seattle, Washington 98104, USA. jbaeten@u.washington.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Anti-Bacterial Agents / administration & dosage, adverse effects Female HIV Seronegativity* HIV-1 / isolation & purification Herpesvirus 2, Human / isolation & purification Humans Hydrogen Peroxide / metabolism Kenya / epidemiology Lactobacillus / isolation & purification* Prospective Studies Prostitution* Risk Factors Soaps / adverse effects Trichomonas Vaginitis / complications Vagina / microbiology* Vaginal Douching / adverse effects Vaginosis, Bacterial / epidemiology* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
|
D43-TW00007/TW/FIC NIH HHS; K23 AI052480-05/AI/NIAID NIH HHS; K23-AI52480/AI/NIAID NIH HHS; N01-A1-35173-119//PHS HHS; P30 AI027757/AI/NIAID NIH HHS; R01-AI33873/AI/NIAID NIH HHS; R01-AI38518/AI/NIAID NIH HHS; R01-AI52480/AI/NIAID NIH HHS; R37 AI038518-09/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Bacterial Agents; 0/Soaps; 7722-84-1/Hydrogen Peroxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Neuromuscular responses to hydration in moderate to warm ambient conditions during self-paced high i...
Next Document: Drug misuse in pregnancy: losing sight of the baby?