Document Detail

Prospective study of childhood acute lymphocytic leukemia: hematologic, immunologic, and cytogenetic correlations.
MedLine Citation:
PMID:  3164089     Owner:  NLM     Status:  MEDLINE    
We studied the karyotype in 81 consecutively diagnosed children with acute lymphocytic leukemia (ALL) treated at one institution on a randomized treatment protocol. In 75 patients (93%), a morphological cytogenetic result was obtained, and 57 (65%) were successfully G-banded. Of the 75 patients, 46 (61%) showed abnormal chromosomes, mainly hyperdiploidy and pseudodiploidy, and 29 had no detectable abnormality. Our findings confirmed that the karyotype has prognostic significance. Duration of complete remission was 93% at 42 months for patients with high hyperdiploidy (greater than 50). For patients with an apparently normal karyotype, it was 58%; and for patients with structural abnormalities it was 15%. The significance of these findings was confirmed by multivariate analysis, which showed age and karyotype to be the most important determinants of duration of remission.
P M Michael; O M Garson; H Ekert; G Tauro; G C Rennie; G R Pilkington
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medical and pediatric oncology     Volume:  16     ISSN:  0098-1532     ISO Abbreviation:  Med. Pediatr. Oncol.     Publication Date:  1988  
Date Detail:
Created Date:  1988-07-18     Completed Date:  1988-07-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7506654     Medline TA:  Med Pediatr Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  153-61     Citation Subset:  IM    
University of Melbourne Department of Medicine, St. Vincent's Hospital, Australia.
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MeSH Terms
Chromosome Aberrations / epidemiology*
Chromosome Banding
Chromosome Disorders
Chromosomes, Human / ultrastructure
Leukemia, Lymphoid / genetics*,  immunology,  mortality
Prospective Studies
Remission Induction

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