| Prospective study of antioxidant micronutrients in the blood and the risk of developing prostate cancer. | |
| | |
MedLine Citation:
|
PMID: 12578804 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Antioxidant micronutrients may have chemopreventive effects. The authors examined the associations between prediagnostic blood levels of micronutrients and prostate cancer risk in two nested case-control studies of 9,804 and 10,456 male residents of Washington County, Maryland, who donated blood in 1974 (CLUE I) and 1989 (CLUE II), respectively. Until 1996, 182 men for whom adequate serum remained for assays in the CLUE I cohort and 142 men in the CLUE II cohort developed prostate cancer. Each case was matched with two controls by age, gender, race, and date of blood donation. In both cohorts, cases and controls had similar concentrations of alpha-carotene, beta-carotene, total carotene, beta-cryptoxanthin, lutein, lycopene, retinol, and ascorbic acid; serum alpha-tocopherol was weakly associated with prostate cancer risk. Higher retinyl palmitate concentrations were associated with a lower risk in CLUE I but not CLUE II. In CLUE I, cases had lower concentrations of gamma-tocopherol than did controls (p = 0.02), but no dose-response trend was observed. A strong inverse association between gamma-tocopherol and prostate cancer risk was observed in CLUE II. Findings do not replicate previous reports of a protective association between lycopene and prostate cancer, but they suggest potential chemopreventive effects of gamma-tocopherol on prostate cancer. |
| | |
Authors:
|
Han-Yao Huang; Anthony J Alberg; Edward P Norkus; Sandra C Hoffman; George W Comstock; Kathy J Helzlsouer |
Related Documents
:
|
447494 - Patterns of gastrointestinal neoplasms in israel. 10648274 - Carotenoids and colon cancer. 15456994 - Phyto-oestrogen intake and breast cancer risk in south asian women in england: findings... 6120284 - Breast cancer and alcoholic-beverage consumption. 16728564 - Molecular links between obesity and breast cancer. 15638964 - Cetuximab as a single agent or in combination with chemotherapy in lung cancer. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: American journal of epidemiology Volume: 157 ISSN: 0002-9262 ISO Abbreviation: Am. J. Epidemiol. Publication Date: 2003 Feb |
Date Detail:
|
Created Date: 2003-02-11 Completed Date: 2003-03-13 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7910653 Medline TA: Am J Epidemiol Country: United States |
Other Details:
|
Languages: eng Pagination: 335-44 Citation Subset: IM |
Affiliation:
|
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205-2223, USA. hyhuang@jhsph.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Antioxidants / metabolism* Case-Control Studies Dose-Response Relationship, Drug Humans Logistic Models Male Maryland / epidemiology Micronutrients / blood* Middle Aged Prospective Studies Prostatic Neoplasms / blood, epidemiology*, etiology Risk Factors Statistics, Nonparametric gamma-Tocopherol / blood* |
| Grant Support | |
ID/Acronym/Agency:
|
CA-94-028/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antioxidants; 0/Micronutrients; 0/gamma-Tocopherol |
| Comments/Corrections | |
Erratum In:
|
Am J Epidemiol. 2003 Jun 15;157(12):1126 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Relation between cognitive function and mortality in middle-aged adults: the atherosclerosis risk in...
Next Document: Antioxidant micronutrients and risk of rheumatoid arthritis in a cohort of older women.