Document Detail


Prospective study of antioxidant micronutrients in the blood and the risk of developing prostate cancer.
MedLine Citation:
PMID:  12578804     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Antioxidant micronutrients may have chemopreventive effects. The authors examined the associations between prediagnostic blood levels of micronutrients and prostate cancer risk in two nested case-control studies of 9,804 and 10,456 male residents of Washington County, Maryland, who donated blood in 1974 (CLUE I) and 1989 (CLUE II), respectively. Until 1996, 182 men for whom adequate serum remained for assays in the CLUE I cohort and 142 men in the CLUE II cohort developed prostate cancer. Each case was matched with two controls by age, gender, race, and date of blood donation. In both cohorts, cases and controls had similar concentrations of alpha-carotene, beta-carotene, total carotene, beta-cryptoxanthin, lutein, lycopene, retinol, and ascorbic acid; serum alpha-tocopherol was weakly associated with prostate cancer risk. Higher retinyl palmitate concentrations were associated with a lower risk in CLUE I but not CLUE II. In CLUE I, cases had lower concentrations of gamma-tocopherol than did controls (p = 0.02), but no dose-response trend was observed. A strong inverse association between gamma-tocopherol and prostate cancer risk was observed in CLUE II. Findings do not replicate previous reports of a protective association between lycopene and prostate cancer, but they suggest potential chemopreventive effects of gamma-tocopherol on prostate cancer.
Authors:
Han-Yao Huang; Anthony J Alberg; Edward P Norkus; Sandra C Hoffman; George W Comstock; Kathy J Helzlsouer
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of epidemiology     Volume:  157     ISSN:  0002-9262     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-11     Completed Date:  2003-03-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  335-44     Citation Subset:  IM    
Affiliation:
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205-2223, USA. hyhuang@jhsph.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Antioxidants / metabolism*
Case-Control Studies
Dose-Response Relationship, Drug
Humans
Logistic Models
Male
Maryland / epidemiology
Micronutrients / blood*
Middle Aged
Prospective Studies
Prostatic Neoplasms / blood,  epidemiology*,  etiology
Risk Factors
Statistics, Nonparametric
gamma-Tocopherol / blood*
Grant Support
ID/Acronym/Agency:
CA-94-028/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Micronutrients; 0/gamma-Tocopherol
Comments/Corrections
Erratum In:
Am J Epidemiol. 2003 Jun 15;157(12):1126

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