Document Detail

Prospective study of Clostridium difficile colonization and paracresol detection in the stools of babies on a special care unit.
MedLine Citation:
PMID:  6747283     Owner:  NLM     Status:  MEDLINE    
Infants' stools were examined for the presence of Clostridium difficile and its cytotoxin in a study performed over a one-year period on a special care baby unit. Overall, 21% of infants were colonized, but the organism was only recovered in a seven-month period during which its weekly prevalence in the group varied from zero to 44%, with a distinct clustering of colonized infants being observed. Tests for the presence of cytotoxin in the stools and in supernatants of broth that had been inoculated with each isolate were negative. The factors predisposing to colonization were a prolonged stay in the unit, low birth weight, younger gestational age and being nursed in an incubator. The organism was recovered only once from an environmental screen. An antibiogram, used in conjunction with toxin production, was helpful in distinguishing these isolates from a collection obtained from other units in the hospital. We conclude that Cl. difficile was acquired by nosocomial spread although we did not establish the precise mechanism involved. The detection of para-cresol by gas-liquid chromatography was found to be specific but insufficiently sensitive as a screening test for the organism's presence in the stools. It could only be demonstrated in infants whose birth-weights were less than 2500 g, and no association was observed between the type of feed and para-cresol presence in stools.
T J Phua; T R Rogers; A P Pallett
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of hygiene     Volume:  93     ISSN:  0022-1724     ISO Abbreviation:  J Hyg (Lond)     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-09-17     Completed Date:  1984-09-17     Revised Date:  2010-09-10    
Medline Journal Info:
Nlm Unique ID:  0375374     Medline TA:  J Hyg (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  17-25     Citation Subset:  IM    
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MeSH Terms
Clostridium / classification,  growth & development,  isolation & purification*
Cresols / analysis*
Feces / analysis,  microbiology*
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature*
Intensive Care Units, Neonatal
Prospective Studies
Time Factors
Reg. No./Substance:
0/Cresols; 106-44-5/4-cresol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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